Fig. 2

Antibodies against VISTA and VISTA deficiency protect mice from collagen antibody-induced arthritis (CAIA). (a, b) DBA/1 J mice or (c–f) C57Bl/6 wild-type (WT) or V-KO (KO) mice were subjected to the CAIA model (n = 6 per group). a Mean arthritis scores of mice treated with anti-VISTA clone MH5A (circles) or hamster Ig (triangles). b Mean arthritis scores of mice treated with anti-VISTA clone 8G8 (circles) or hamster IgG (triangles). c Mean arthritis scores for WT mice (blue triangles) and V-KO mice (red circles). d Representative hind paws of WT and KO mice on day 13. e Representative H&E-stained tissue sections of the central aspect of knee joints from WT and KO mice on day 13. f Cumulative histology scores for pannus, cartilage loss, and bone erosions for knee, ankle, and paw tissue sections from WT mice (blue bars) and V-KO mice (red bars) on day 13