Fig. 8From: Role of endoplasmic reticulum stress in the protective effects of PPARβ/δ activation on endothelial dysfunction induced by plasma from patients with lupusProposed mechanism of the protective effects of PPARβ/δ activation in systemic lupus erythematosus (SLE) endothelial dysfunction. SLE plasma incubation induced endothelial dysfunction in human umbilical cord vein endothelial cells (HUVECs) by sequential activation of endoplasmic reticulum (ER)-stress and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase. PPARβ/δ activation inhibited both ER stress and NADPH oxidase-driven reactive oxygen species (ROS) production reducing nitric oxide (NO) inactivation. AN, active nephritisBack to article page