Angiogenesis and VEGF-expressing cells are identified predominantly in the fascia rather than in the muscle during the early phase of dermatomyositis

Yoshida, Ken; Ito, Haruyasu; Furuya, Kazuhiro; Ukichi, Taro; Noda, Kentaro; Kurosaka, Daitaro

doi:10.1186/s13075-017-1481-z

Table 1 The clinical characteristics of the patients DM (n = 22) and PM (n = 11)

From: Angiogenesis and VEGF-expressing cells are identified predominantly in the fascia rather than in the muscle during the early phase of dermatomyositis

Number	Diagnosis	ILD	Cancer	CK	Jo1	ARS	Other^a	Fasciitis^b	Duration^c	Biopsy site
DM
1	Definite	No	Yes	249	N	NA	NA	+	1 week	Sartorius
2	Definite	Yes	Yes	303	N	NA	NA	+/–	2 weeks	Biceps brachii
3	Definite	Yes	No	1491	N	N	Ku	+	2 weeks	Biceps brachii
4	Definite	Yes	No	470	N	N	MDA5	+/–	2 weeks	Deltoid
5	Probable	Yes	No	480	N	NA	NA	+/–	3 weeks	Deltoid
6	Definite	Yes	No	176	N	N	N	+/–	3 weeks	Deltoid
7	Definite	Yes	No	1823	N	N	N	+/–	4 weeks	Biceps brachii
8	Definite	No	No	363	N	N	N	+	4 weeks	Rectus femoris
9	Probable	Yes	No	229	N	NA	NA	+	5 weeks	Biceps brachii
10	Definite	Yes	No	2833	P	P	NA	+	6 weeks	Biceps brachii
11	Probable	Yes	No	751	P	NA	NA	+	6 weeks	Biceps brachii
12	Definite	No	No	77	N	NA	NA	+	7 weeks	Biceps brachii
13	Definite	Yes	Yes	246	N	N	N	+	2 months	Triceps brachii
14	Definite	No	No	6530	N	N	Mi-2	+	2 months	Biceps brachii
15	Definite	No	No	895	N	N	Mi-2	+	2 months	Biceps brachii
16	Definite	No	Yes	246	N	NA	NA	+	3 months	Biceps brachii
17	Definite	No	Yes	1342	N	NA	NA	+	3 months	Deltoid
18	Probable	Yes	No	2428	P	P	N	+	4 months	Biceps brachii
19	Definite	Yes	No	35	N	NA	NA	+	4 months	Deltoid
20	Definite	No	No	415	N	N	Mi-2	+	5 months	Biceps brachii
21	Definite	Yes	No	1683	N	P	N	+	6 months	Biceps brachii
22	Definite	No	No	82	N	N	N	+	1 year	Sartorius
PM
23	Probable	Yes	No	615	N	N	NA	+/–	5 weeks	Pectoralis major
24	Probable	No	No	1387	N	N	NA	–	3 months	Vastus medialis
25	Probable	No	No	1681	N	N	NA	–	3.5 months	Triceps brachii
26	Probable	Yes	No	1691	N	N	SRP	–	5 months	Semimembranous
27	Probable	No	No	4304	N	N	NA	–	6 months	Triceps brachii
28	Probable	No	No	1323	N	N	NA	–	9 months	Biceps brachii
29	Probable	No	Yes	2029	N	NA	NA	–	1 year	Sartorius
30	Probable	No	No	156	N	P	NA	+/–	2 years	Vastus lateralis
31	Definite	No	No	486	P	NA	NA	–	3 years	Vastus medialis
32	Definite	No	No	1583	N	N	N	+/–	6 years	Vastus lateralis
33	Probable	Yes	No	254	N	P	N	+/–	NA	Semimembranous

DM dermatomyositis, PM polymyositis, ILD interstitial lung disease, CK creatine kinase, Jo1 anti-Jo-1 antibodies, ARS anti-ARS antibodies including anti-Jo-1 antibodies detected by EUROLINE or MESACUP^TM, N negative, P positive, NA not available
^aOther myositis-specific/associated antibodies detected by EUROLINE or MESACUP^TM (anti-Mi-2, anti-MDA5, anti-SRP, or anti-Ku antibodies), Ku anti-Ku antibodies, MDA5 anti-melanoma differentiation-associated gene 5 antibodies, Mi-2 anti-Mi-2 antibodies, SRP anti-signal recognition particle antibodies
^bPlus symbol (+) represents histological significant fasciitis (TVIS ≥ 3), Plus or minus symbol (+/–) represents histological mild fasciitis (0 < TVIS < 3), minus symbol (–) represents no inflammatory cell infiltration in the fascia (TVIS = 0)
^cDuration is the period from the onset of muscle symptoms at the site of en bloc biopsy up to the biopsy

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ISSN: 1478-6362

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