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Table 1 Patient and control characteristics

From: Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

  

cSLE

 

HC (n = 13)

IFNpos (n = 13)

IFNneg (n = 10)

 

Demographics

 Ethnicity

  White

13/13 (100%)

9/13 (69%)

7/10 (70%)

Nsc

  Non-white

0/13 (0%)

4/13 (31%)

3/10 (30%)

Nsc

 Gender

  Male (%)

3/13 (23%)

2/13 (15%)

2/10 (20%)

Nsc

  Female (%)

10/13 (77%)

11/13 (85%)

8/10 (80%)

Nsc

 Median age (years)

22 (15 ± 25)

15.8 (4.8 ± 18.2)

15.1 (9.3 ± 17.5)

Nsa

 Disease duration (years)

-

0.85 (0 ± 3.4)

1.5 (0 ± 4.7)

Nsb

 SELENA-SLEDAI

-

4 (0 ± 20)

3 (0 ± 13)

Nsb

Laboratory parameters

 ANA

-

12/13 (92%)

9/10 (90%)

Nsc

 Anti-ds-DNA

-

4/13 (31%)

2/10 (20%)

Nsc

 Anti-Ro52/Ro60

-

6/13 (46%)

0/10 (0%)

p = 0.019c

 Anti-La

-

2/13 (15%)

0/10 (0%)

Nsc

 Anti-RNP

-

5/13 (31%)

0/10 (0%)

p = 0.046c

 C3 (g/l)

-

0.89 (0.3 ± 1.27)

1.1 (0.77 ± 1.72)

p =0.014b

 C4 (g/l)

-

0.16 (0.02 ± 0.2)

0.19 (0.1 ± 0.37)

p = 0.049b

 IgG (g/l)

-

10.3 (7.1 ± 27.6)

9.6 (8.4 ± 28)

Nsb

Medication (%)

 Hydroxychloroquine

-

10/13 (77%)

10/10 (100%)

Nsc

 Mycofenolaatmofetil

-

3/13 (23%)

6/10 (60%)

Nsc

 Prednisone

-

6/13 (46%)

5/10 (50%)

Nsc

 Other medication

-

5/13 (38%)

5/10 (50%)

Nsc

  1. Data are presented as median (IQR) or as number (%) of patients according to data distribution. Non-white ethnicity = Hindu and Suriname.
  2. SELENA Safety of Estrogens in Lupus National Assessment, SLEDAI Systemic Lupus Erythematosus Disease Activity Index, ANA antinuclear antibody, Anti-RNP antibodies to ribonucleoprotein, C complement, IgG immunoglobulin, cSLE childhood-onset systemic lupus erythematosus, IFNpos interferon (IFN) signature positive, IFNneg IFN signature negative, HC healthy control, Ns not significant
  3. aGroups compared using the Kruskal-Wallis test (three groups)
  4. bGroups compared using the Mann-Whitney U test (two groups)
  5. cGroups compared using Fisher’s exact test (categorical data)