Fig. 3

Confirmation of the effects of B cells from naïve DBA1/J mice (N-B; control) and anti-BANK1 antibody/N-B-treated CD4⁺ T cells (pre-treated CD4⁺ T cells) in vivo. a Clinical scores were recorded every other day after immunization. b-d. Anti-collagen type II (anti-CII) antibody levels in serum were detected using an ELISA. e The BANK1 mRNA levels in each group were detected. Bars show the means ± SEM of pooled data from three independent experiments. At least five mice were included in each group: *P < 0.05 and **P < 0.01 for comparison of the indicated groups using the unpaired t test. CIA collagen-induced arthritis, d days