Table 1 Candidate proteins differentially expressed between SLE patients and controls
UniProt Accession number | Protein name | Gene name | Location | Function | Fold change | ANOVA (p) |
|---|---|---|---|---|---|---|
Q8WU39 | Marginal zone B and B1 cell-specific protein | MZB1 | ER | Immunoglobulin folding and secretion | 2.5 | 0.03 |
P28838 | Cytosol aminopeptidase | LAP3 | Cytoplasm | Presumably involved in the processing and regular turnover of intracellular proteins | 2.0 | 0.04 |
P07900 | Heat shock protein HSP 90-alpha | HSP90AA1 | Cytoplasm | Molecular chaperone | 1.9 | 0.03 |
P43243 | Matrin-3 | MATR3 | Nucleus | May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network | 1.7 | 0.03 |
P67809 | Nuclease-sensitive element-binding protein 1 | YBX1 | Cytoplasm, nucleus, secreted | Extracellular mitogen and stimulates cell migration and proliferation | 2.1 | 0.05 |
P36578 | 60S ribosomal protein L4 | RPL4 | Cytoplasm | Ribosomal protein | 1.6 | 0.05 |
P00488 | Coagulation factor XIII A chain | F13A1 | Cytoplasm, secreted | Stabilizes fibrin clots | –24 | 0.01 |
Q9Y3U8 | 60S ribosomal protein L36 | RPL36 | Cytoplasm | Ribosomal protein | –1.7 | 0.04 |
Q16658 | Fascin | FSCN1 | Cytoplasm | Plays a role in the organization of actin filament bundles | –1.5 | 0.03 |