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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice

Fig. 3

Representative flow cytometric profiles of spleen cells (a), peripheral leukocytes (b), and peripheral CD115+ monocytes (c) in untreated and anti-mouse CD11b monoclonal antibody (5C6)-treated FcγRIIB-deficient mouse strain (KO1) mice at 10 months of age. a Spleen cells were stained with fluorescent-labeled CD69/B220, peanut agglutinin (PNA)/B220, and CD138/B220. The frequencies of CD69+ activated B cells and of PNA+ germinal center B cells per total B cells are shown as squares. The frequencies of CD138+ plasma cells and B220+ B cells per total cells are shown as circles. b Peripheral leukocytes were stained with fluorescent-labeled Gr-1/CD11b. The frequencies of neutrophils, monocytes of Gr-1+ and Gr-1- subsets per total cell are shown as squares. c Peripheral leukocytes were stained with fluorescent-labeled CD115/Gr-1/CD11b. Gr-1/CD11b expression profiles of CD115+ gated monocytes clearly show Gr-1+ and Gr-1- monocyte subsets

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