Skip to main content


Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner

Fig. 1

Anticitrullinated protein antibodies (ACPA)- and rheumatoid factor (RF)-induced cytokine production in monocytes. Levels of interleukin (IL)-6, IL-1β, IL-8, tumor necrosis factor (TNF)-α, and chemokine ligand 2 (CCL2) were measured in the supernatants of monocytes stimulated with 100 μg/ml ACPA immune complexes or RF or with 0.5 ng/ml lipopolysaccharide (LPS; positive control). ***p < 0.01. BL Baseline (exposure to random immunoglobulin G, negative control)

Back to article page