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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner

Fig. 2

Cytotoxic T-lymphocyte-associated antigen 4 immunoglobulin (CTLA-4-Ig) blocks autoantibody-mediated cytokine production by monocytes. Levels of interleukin (IL)-6, IL-1β, IL-8, tumor necrosis factor (TNF)-α, and chemokine ligand 2 (CCL2) were measured in the supernatants of monocytes stimulated with 100 μg/ml anticitrullinated protein antibody (ACPA) immune complexes or rheumatoid factor (RF). Cultures were exposed to either 10 μg/ml CTLA-4-Ig (abatacept) or anti-TNF antibody (Ab) adalimumab. BL, baseline (neither CTLA-4-Ig/abatacept nor anti-TNF antibody/adalimumab present). ***p < 0.01

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