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Table 3 Serum levels of collagen II antibodies after 2 weeks of treatment in collagen-induced arthritis mice

From: Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Treatments

Anti-collagen II (μg/ml)

P value

Vehicle

757.45 ± 89.18

–

30 mg/kg CR6086

324.91 ± 79.82

0.0042

1 mg/kg MTX

483.83 ± 102.82

0.2889

3 mg/kg MTX

242.46 ± 79.35

0.0012

1 mg/kg MTX + 30 mg/kg CR6086

389.50 ± 65.84

0.0314

3 mg/kg MTX + 30 mg/kg CR6086

236.60 ± 50.75

0.0015

  1. MTX Methotrexate
  2. P values calculated by Dunnett’s multiple comparisons test vs vehicle-treated animals
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Arthritis Research & Therapy

ISSN: 1478-6362

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