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Fig. 9 | Arthritis Research & Therapy

Fig. 9

From: Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity

Fig. 9

Correlation of immunoglobulin G (IgG) hypogalactosylation with disease activity in seropositive and seronegative rheumatoid arthritis (RA). Relationship between IgG agalactosylated immunoglobulin G/monogalactosylated immunoglobulin G (G0/G1) ratio and activity markers ((a) Disease Activity Score in 28 joints [DAS28], (b) C-reactive protein [CRP], and (c) erythrocyte sedimentation rate [ESR]) in RA, stratified by seropositive (sero+ anticitrullinated protein antibody [ACPA] and/or sero+ rheumatoid factor [RF]) and seronegative (sero− ACPA and sero− RF) status. Results of regression analyses and 95% CIs are given, as well as p values for heterogeneity. Sex is indicated by upright triangles (female) and inverted triangles (male). In regard to multiple testing, a Bonferroni-corrected p value of p < 0.0042 should be applied

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