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Table 2 Serum levels of TNF-α and IL-18

From: Traditional Chinese medicine formula Bi-Qi capsule alleviates rheumatoid arthritis-induced inflammation, synovial hyperplasia, and cartilage destruction in rats

Group (n = 8)

TNF-α (pg/ml)

IL-18 (pg/ml) week 6

week 2

week 6

Healthy

22.71 ± 1.79

23.87 ± 5.11

30.28 ± 1.76

Arthritic

43.15 ± 1.57****

39.80 ± 4.38****

38.03 ± 3.35**

BQ-high dose

43.35 ± 1.84****

34.04 ± 5.22**

33.69 ± 4.36

BQ-moderate dose

42.68 ± 2.30****

31.87 ± 2.88*, ∆

32.37 ± 4.20∆

MTX

43.28 ± 2.29****

33.84 ± 4.39**

32.32 ± 3.61∆

  1. Data are presented as mean ± SD
  2. BQ Bi-Qi capsule, MTX methotrexate
  3. Significant effect of treatment compared to control, **P < 0.01, ****P < 0.0001; compared to arthritic group, ∆P < 0.05