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Table 2 Serum levels of TNF-α and IL-18

From: Traditional Chinese medicine formula Bi-Qi capsule alleviates rheumatoid arthritis-induced inflammation, synovial hyperplasia, and cartilage destruction in rats

Group (n = 8) TNF-α (pg/ml) IL-18 (pg/ml) week 6
week 2 week 6
Healthy 22.71 ± 1.79 23.87 ± 5.11 30.28 ± 1.76
Arthritic 43.15 ± 1.57**** 39.80 ± 4.38**** 38.03 ± 3.35**
BQ-high dose 43.35 ± 1.84**** 34.04 ± 5.22** 33.69 ± 4.36
BQ-moderate dose 42.68 ± 2.30**** 31.87 ± 2.88*, ∆ 32.37 ± 4.20
MTX 43.28 ± 2.29**** 33.84 ± 4.39** 32.32 ± 3.61
  1. Data are presented as mean ± SD
  2. BQ Bi-Qi capsule, MTX methotrexate
  3. Significant effect of treatment compared to control, **P < 0.01, ****P < 0.0001; compared to arthritic group, P < 0.05