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Table 1 Baseline demographics and disease characteristics

From: Clinical and MRI remission in patients with nonradiographic axial spondyloarthritis who received long-term open-label adalimumab treatment: 3-year results of the ABILITY-1 trial

Characteristic, mean (SD) Total efficacy population (N = 185) MRI/CRP-positive subpopulation (n = 142) MRI- and CRP-negative subpopulation (n = 43)a
Female, n (%) 101 (54.6) 77 (54.2) 24 (55.8)
Age, years 38.0 (10.8) 38.3 (11.1) 37.2 (10.1)
Symptom duration, years 10.0 (8.9)b 10.5 (9.4)c 8.3 (6.6)d
HLA-B27 positive, n (%) 145 (78.4) 114 (80.3) 31 (72.1)
BASDAI (0–10) 6.5 (1.5) 6.4 (1.5) 6.7 (1.5)
ASDAS (0–10) 3.3 (0.8)e 3.4 (0.8)f 2.9 (0.6)d
Patient Global Assessment of Disease Activity (0–10 cm VAS) 6.8 (1.8) 6.8 (1.9) 6.8 (1.8)
Physician Global Assessment of Disease Activity (0–10 cm VAS) 5.7 (1.6)g 5.6 (1.6) 6.1 (1.7)h
Total back pain (0–10 cm VAS) 6.9 (1.8) 6.8 (1.8) 7.3 (1.5)
BASFI (0–10) 4.7 (2.1)g 4.7 (2.2)i 4.8 (2.0)
Inflammation/morning stiffnessj (0–10 cm VAS) 6.6 (2.0) 6.6 (2.1) 6.7 (1.7)
Elevated baseline CRP,k n (%) 48 (33.6)l 48 (46.2)m 0
CRP, k mg/L 7.2 (11.0) 9.0 (12.0) 1.4 (1.1)
SPARCC MRI score, SIJ 4.9 (9.7)n 6.3 (10.7)c 0.4 (0.5)h
SPARCC MRI score, spine 4.3 (5.8)o 5.5 (6.1)p 0.5 (0.6)h
HAQ-S (0–3) 1.0 (0.6) 1.0 (0.5) 1.1 (0.6)
BASMI linear (0–10) 2.7 (1.2)g 2.7 (1.3)i 2.7 (1.1)
  1. Abbreviations: ASDAS Ankylosing Spondylitis Disease Activity Score, BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Functional Index, BASMI Bath Ankylosing Spondylitis Metrology Index, CRP C-reactive protein, HAQ-S Health Assessment Questionnaire for the Spondyloarthropathies, HLA-B27 human leukocyte antigen B27, MRI Magnetic resonance imaging, SPARCC Spondyloarthritis Research Consortium of Canada, VAS Visual analogue scale
  2. aThe baseline data for the MRI- and CRP-negative subpopulation includes 42 patients with confirmed absence of MRI inflammation and normal CRP at baseline and 1 patient with normal CRP but missing baseline MRI,bn = 180,cn = 140,dn = 40,en = 178,fn = 138,gn = 184,hn = 42,in = 141,jMean of BASDAI questions 5 and 6,kBased on either standard or high-sensitivity CRP values,ln = 143,mn = 104,nn = 182,on = 181,pn = 139