Fig. 5
From: CCL17 blockade as a therapy for osteoarthritis pain and disease
Therapeutic inhibition of cyclooxygenase 2 (COX-2) ameliorates collagenase-induced osteoarthritis (CiOA) pain, but not disease development. Wild-type (WT) mice were induced with CiOA on day 0 and treated therapeutically from day 23 with either dimethyl sulfoxide (DMSO) or the COX-2 specific inhibitor, SC58128 (1 mg/kg, i.p.) weekly. a Change in weight distribution (pain) over time. b Representative histologic pictures of knee joints (Safranin O/fast green stain, original magnification ×100) and quantification of arthritis at day 42. c Representative histologic pictures of osteophytes (indicated by arrow) (Safranin O/fast green stain; original magnification ×100) and quantification of osteophyte size. Results are expressed as the mean ± SEM; n = 5 mice per strain. i.a., intra-articular. *p < 0.05, **p < 0.01, ***p < 0.001, DMSO vs. SC58125