Skip to main content

Table 2 Selected cardiac, renal, and infectious codes from the PheWAS of African Americans compared to Caucasians with SLE

From: Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus

PheWAS code name (code number) Phenotype present (≥ 2 instances of PheWAS code)a Phenotype absent (0 instances of PheWAS code)a Adjusted odds ratio for current age and sex (95% CI) False discovery rate pb
Selected cardiac codes
 Hypertension (401) 423 494 African American, 4.25 (3.05–5.92)
Caucasian, 1.00 (ref)
5.49 × 10− 15
 Other forms of chronic heart disease (414) 30 790 9.10 (3.94–20.98) 2.69 × 10− 6
 Congestive heart failure (428) 86 702 3.53 (2.15–5.78) 5.63 × 10−6
 Cerebrovascular disease (433) 85 841 2.80 (1.69–4.65) 4.23 × 10−4
 Other venous embolism and thrombosis (452) 89 741 2.58 (1.62–4.13) 4.47 × 10−4
 Heart valve disorders (395) 68 794 2.89 (1.69–4.95) 5.52 × 10−4
 Pulmonary embolism and infarction, acute (415.11) 28 785 3.73 (1.69–8.23) 4.03 × 10− 3
 Cardiomyopathy (425) 27 823 2.87 (1.29–6.41) 0.03
 Peripheral vascular disease (443.9) 25 738 3.16 (1.27–7.90) 0.04
 Atherosclerosis (440) 24 738 2.99 (1.22–7.37) 0.04
 Cardiac dysrhythmias (427) 171 684 1.60 (1.08–2.36) 0.04
Selected renal codes
 Renal dialysis (585.31) 73 600 10.90 (6.11–19.48) 8.75 × 10−14
 End stage renal disease (585.32) 76 600 8.57 (4.97–14.79) 7.15 × 10−13
 Hypertensive chronic kidney disease (401.22) 103 494 6.63 (4.08–10.77) 1.24 × 10−12
 Acute renal failure (585.1) 149 600 4.43 (2.98–6.60) 1.05 × 10−11
 Chronic renal failure (CKD) (512) 169 600 3.64 (2.49–5.33) 7.08 × 10−10
 Kidney replaced by transplant (587) 49 600 7.67 (3.98–14.78) 2.32 × 10− 8
 Nephritis; nephrosis; renal sclerosis (512.7) 188 600 3.03 (2.10–4.37) 5.60 × 10− 8
 Glomerulonephritis (580.1) 90 600 4.10 (2.53–6.65) 1.66 × 10−7
Selected infection codes
 Pneumonia (480) 128 701 3.57 (2.37–5.38) 2.32 × 10−8
 Superficial cellulitis and abscess (681) 92 793 2.56 (1.61–4.06) 4.30 × 10−4
 Pyelonephritis (590) 29 538 4.45 (2.03–9.74) 9.20 × 10− 4
 Bacteremia (038.3) 58 894 2.83 (1.62–4.95) 1.18 × 10−3
 Candidiasis (112) 72 806 2.57 (1.54–4.29) 1.23 × 10− 3
 Cellulitis and abscess of trunk (681.7) 22 793 5.62 (2.18–14.45) 1.41 × 10−3
 Sepsis and SIRS (994) 66 888 1.88 (1.10–3.20) 0.05
  1. SLE systemic lupus erythematosus, PheWas phenome-wide association studies, SIRS systemic inflammatory response syndrome
  2. aPhenotype present indicates subjects who had the code listed on at least two instances vs. phenotype absent indicates subjects who did not have the code or related codes. Subjects with one instance of a code are excluded, so the total number of subjects for each PheWAS code does not add up to the 1097 subjects with SLE
  3. bCodes listed met the false discovery rate of 0.05