Table 2 Selected cardiac, renal, and infectious codes from the PheWAS of African Americans compared to Caucasians with SLE
PheWAS code name (code number) | Phenotype present (≥ 2 instances of PheWAS code)a | Phenotype absent (0 instances of PheWAS code)a | Adjusted odds ratio for current age and sex (95% CI) | False discovery rate pb |
|---|---|---|---|---|
Selected cardiac codes | ||||
 Hypertension (401) | 423 | 494 | African American, 4.25 (3.05–5.92) Caucasian, 1.00 (ref) | 5.49 × 10− 15 |
 Other forms of chronic heart disease (414) | 30 | 790 | 9.10 (3.94–20.98) | 2.69 × 10− 6 |
 Congestive heart failure (428) | 86 | 702 | 3.53 (2.15–5.78) | 5.63 × 10−6 |
 Cerebrovascular disease (433) | 85 | 841 | 2.80 (1.69–4.65) | 4.23 × 10−4 |
 Other venous embolism and thrombosis (452) | 89 | 741 | 2.58 (1.62–4.13) | 4.47 × 10−4 |
 Heart valve disorders (395) | 68 | 794 | 2.89 (1.69–4.95) | 5.52 × 10−4 |
 Pulmonary embolism and infarction, acute (415.11) | 28 | 785 | 3.73 (1.69–8.23) | 4.03 × 10− 3 |
 Cardiomyopathy (425) | 27 | 823 | 2.87 (1.29–6.41) | 0.03 |
 Peripheral vascular disease (443.9) | 25 | 738 | 3.16 (1.27–7.90) | 0.04 |
 Atherosclerosis (440) | 24 | 738 | 2.99 (1.22–7.37) | 0.04 |
 Cardiac dysrhythmias (427) | 171 | 684 | 1.60 (1.08–2.36) | 0.04 |
Selected renal codes | ||||
 Renal dialysis (585.31) | 73 | 600 | 10.90 (6.11–19.48) | 8.75 × 10−14 |
 End stage renal disease (585.32) | 76 | 600 | 8.57 (4.97–14.79) | 7.15 × 10−13 |
 Hypertensive chronic kidney disease (401.22) | 103 | 494 | 6.63 (4.08–10.77) | 1.24 × 10−12 |
 Acute renal failure (585.1) | 149 | 600 | 4.43 (2.98–6.60) | 1.05 × 10−11 |
 Chronic renal failure (CKD) (512) | 169 | 600 | 3.64 (2.49–5.33) | 7.08 × 10−10 |
 Kidney replaced by transplant (587) | 49 | 600 | 7.67 (3.98–14.78) | 2.32 × 10− 8 |
 Nephritis; nephrosis; renal sclerosis (512.7) | 188 | 600 | 3.03 (2.10–4.37) | 5.60 × 10− 8 |
 Glomerulonephritis (580.1) | 90 | 600 | 4.10 (2.53–6.65) | 1.66 × 10−7 |
Selected infection codes | ||||
 Pneumonia (480) | 128 | 701 | 3.57 (2.37–5.38) | 2.32 × 10−8 |
 Superficial cellulitis and abscess (681) | 92 | 793 | 2.56 (1.61–4.06) | 4.30 × 10−4 |
 Pyelonephritis (590) | 29 | 538 | 4.45 (2.03–9.74) | 9.20 × 10− 4 |
 Bacteremia (038.3) | 58 | 894 | 2.83 (1.62–4.95) | 1.18 × 10−3 |
 Candidiasis (112) | 72 | 806 | 2.57 (1.54–4.29) | 1.23 × 10− 3 |
 Cellulitis and abscess of trunk (681.7) | 22 | 793 | 5.62 (2.18–14.45) | 1.41 × 10−3 |
 Sepsis and SIRS (994) | 66 | 888 | 1.88 (1.10–3.20) | 0.05 |