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Table 3 Univariate logistic regression analysis of risk factors for remission induction failure 

From: Failure of remission induction by glucocorticoids alone or in combination with immunosuppressive agents in IgG4-related disease: a prospective study of 215 patients

  GC monotherapy GC + IM combination therapy
OR (95% CI) p value OR (95% CI) p value
Male sex 1.07 (0.33, 3.51) 0.907 4.24 (0.52, 34.6) 0.177
Age (continuous) 0.97 (0.93, 1.01) 0.103 1 (0.95, 1.05) 0.901
Disease duration (≥12 months) 1.02 (0.34, 3.1) 0.971 0.39 (0.1, 1.58) 0.186
Allergy history 1.51 (0.49, 4.68) 0.474 2.12 (0.52, 8.58) 0.291
Eosinophilia 7.27 (2.05, 25.74) 0.002 1.46 (0.39, 5.48) 0.576
Elevation of ESR 1.13 (0.33, 3.88) 0.847 1.03 (0.24, 4.54) 0.966
Elevation of CRP 1.65 (0.4, 6.86) 0.493 1.22 (0.28, 5.39) 0.791
IgG
 First quartile (median 12.78 g/L) Ref Ref Ref Ref
 Second quartile (median 17.25 g/L) 0.50 (0.08, 3.15) 0.461 0.94 (0.12, 7.08) 0.949
 Third quartile (median 21.30 g/L) 1.13 (0.21, 6.14) 0.892 1.76 (0.3, 10.31) 0.532
 Fourth quartile (median 31.67 g/L) 1.41 (0.33, 5.98) 0.644 1.12 (0.15, 8.49) 0.916
IgG4
 IgG4 ≤3 × ULN Ref Ref Ref Ref
 3 × ULN <IgG4 ≤10 × ULN 1 (0.2, 5.04) 1 Refa Refa
 10 × ULN <IgG4 ≤20 × ULN 1.64 (0.28, 9.58) 0.585 1.46 (0.35, 6.05) 0.604
 IgG4 >20 × ULN 4.5 (0.89, 22.67) 0.068 NAb NAb
IgE
 First quartile (median 75.5 kU/L) Ref Ref Ref Ref
 Second quartile (median 203 kU/L) 1.45 (0.11, 18.96) 0.775 4.5 (0.44, 46.38) 0.206
 Third quartile (median 529 kU/L) 1.07 (0.08, 13.65) 0.96 1.67 (0.1, 28.32) 0.724
 Fourth quartile (median 1403 kU/L) 3.64 (0.35, 37.46) 0.278 3.16 (0.27, 37.27) 0.361
RI
 First quartile (median 7) Ref Ref Ref Ref
 Second quartile (median 13) 0.95 (0.12, 7.44) 0.961 1.82 (0.24, 13.81) 0.563
 Third quartile (median 16) 2.92 (0.47, 18.37) 0.253 1.08 (0.14, 8.07) 0.939
 Fourth quartile (median 21) 8.44 (1.48, 48.14) 0.016 2.76 (0.47, 16.09) 0.259
Number of organs involved
 1 ~ 2 Ref Ref Ref Ref
 3 ~ 4 2.86 (0.69, 11.93) 0.148 0.92 (0.2, 4.34) 0.921
 ≥ 5 9.67 (1.74, 53.84) 0.01 1.87 (0.35, 10.02) 0.465
Organ involvement
 Mikulicz’s disease 4.54 (0.95, 21.78) 0.059 0.56 (0.15, 2.04) 0.38
  Dacryoadenitis 3.39 (1.05, 10.99) 0.042 1.33 (0.37, 4.81) 0.667
  Sialoadenitis 1.63 (0.51, 5.28) 0.412 0.75 (0.21, 2.73) 0.667
 Autoimmune pancreatitis 1.35 (0.45, 4.06) 0.598 0.94 (0.25, 3.51) 0.931
 Sclerosing cholangitis 0.8 (0.23, 2.8) 0.723 2 (0.53, 7.54) 0.306
 Retroperitoneal fibrosis NAb NAb 0.25 (0.03, 2.07) 0.2
 Lung disease 2.73 (0.82, 9.09) 0.103 1.41 (0.38, 5.29) 0.606
Initial GC dose 1.03 (0.97, 1.1) 0.271 0.97 (0.9, 1.05) 0.441
GC tapered before week 4 0.75 (0.2, 2.83) 0.671 0.41 (0.08, 2.06) 0.279
  1. Abbreviations: GC glucocorticoid, IM immunosuppressive agents, RI responder index, ESR erythrocyte sedimentation rate, CRP hyper-sensitivity C-reactive protein, OR odds ratio, Ref reference, ULN upper limit of normal, NA not applicable
  2. aThe first two groups were combined as 0% remission induction failure occurred in the patients with IgG4 ≤3 × ULN
  3. bNot applicable as 0% remission induction failure occurred in certain groups