Table 3 Univariate logistic regression analysis of risk factors for remission induction failure 

Male sex

1.07 (0.33, 3.51)

0.907

4.24 (0.52, 34.6)

0.177

Age (continuous)

0.97 (0.93, 1.01)

0.103

1 (0.95, 1.05)

0.901

Disease duration (≥12 months)

1.02 (0.34, 3.1)

0.971

0.39 (0.1, 1.58)

0.186

Allergy history

1.51 (0.49, 4.68)

0.474

2.12 (0.52, 8.58)

0.291

Eosinophilia

7.27 (2.05, 25.74)

0.002

1.46 (0.39, 5.48)

0.576

Elevation of ESR

1.13 (0.33, 3.88)

0.847

1.03 (0.24, 4.54)

0.966

Elevation of CRP

1.65 (0.4, 6.86)

0.493

1.22 (0.28, 5.39)

0.791

 First quartile (median 12.78 g/L)

Ref

Ref

Ref

Ref

 Second quartile (median 17.25 g/L)

0.50 (0.08, 3.15)

0.461

0.94 (0.12, 7.08)

0.949

 Third quartile (median 21.30 g/L)

1.13 (0.21, 6.14)

0.892

1.76 (0.3, 10.31)

0.532

 Fourth quartile (median 31.67 g/L)

1.41 (0.33, 5.98)

0.644

1.12 (0.15, 8.49)

0.916

 IgG4 ≤3 × ULN

Ref

Ref

Ref

Ref

 3 × ULN <IgG4 ≤10 × ULN

1 (0.2, 5.04)

1

Ref^a

Ref^a

 10 × ULN <IgG4 ≤20 × ULN

1.64 (0.28, 9.58)

0.585

1.46 (0.35, 6.05)

0.604

 IgG4 >20 × ULN

4.5 (0.89, 22.67)

0.068

NA^b

NA^b

 First quartile (median 75.5 kU/L)

Ref

Ref

Ref

Ref

 Second quartile (median 203 kU/L)

1.45 (0.11, 18.96)

0.775

4.5 (0.44, 46.38)

0.206

 Third quartile (median 529 kU/L)

1.07 (0.08, 13.65)

0.96

1.67 (0.1, 28.32)

0.724

 Fourth quartile (median 1403 kU/L)

3.64 (0.35, 37.46)

0.278

3.16 (0.27, 37.27)

0.361

 First quartile (median 7)

Ref

Ref

Ref

Ref

 Second quartile (median 13)

0.95 (0.12, 7.44)

0.961

1.82 (0.24, 13.81)

0.563

 Third quartile (median 16)

2.92 (0.47, 18.37)

0.253

1.08 (0.14, 8.07)

0.939

 Fourth quartile (median 21)

8.44 (1.48, 48.14)

0.016

2.76 (0.47, 16.09)

0.259

 1 ~ 2

Ref

Ref

Ref

Ref

 3 ~ 4

2.86 (0.69, 11.93)

0.148

0.92 (0.2, 4.34)

0.921

 ≥ 5

9.67 (1.74, 53.84)

0.01

1.87 (0.35, 10.02)

0.465

 Mikulicz’s disease

4.54 (0.95, 21.78)

0.059

0.56 (0.15, 2.04)

0.38

  Dacryoadenitis

3.39 (1.05, 10.99)

0.042

1.33 (0.37, 4.81)

0.667

  Sialoadenitis

1.63 (0.51, 5.28)

0.412

0.75 (0.21, 2.73)

0.667

 Autoimmune pancreatitis

1.35 (0.45, 4.06)

0.598

0.94 (0.25, 3.51)

0.931

 Sclerosing cholangitis

0.8 (0.23, 2.8)

0.723

2 (0.53, 7.54)

0.306

 Retroperitoneal fibrosis

NA^b

NA^b

0.25 (0.03, 2.07)

0.2

 Lung disease

2.73 (0.82, 9.09)

0.103

1.41 (0.38, 5.29)

0.606

Initial GC dose

1.03 (0.97, 1.1)

0.271

0.97 (0.9, 1.05)

0.441

GC tapered before week 4

0.75 (0.2, 2.83)

0.671

0.41 (0.08, 2.06)

0.279