Fig. 1

Fcγ receptor (FcγR)I,II,III,IV^−/− mice have decreased bone erosion compared with wild-type (WT) control mice. a Bone erosion (black arrows) is present in the joints of FcγRI,II,III,IV^−/− and WT mice after induction of antigen-induced arthritis (AIA), as determined by using H&E-stained sections. Original magnification ×50 and ×200. b Quantification of bone erosion showed significantly decreased resorption in the joints of FcγRI,II,III,IV^−/− mice compared with their WT controls (n = 17 and 24 joints per group respectively) at both 7 and 21 days after AIA induction. No basal differences in bone erosion could be observed in the joints of naive mice. Scatterplots are shown, with horizontal and vertical lines representing mean ± SEM values. ns Not significant. ** P < 0.01, *** P < 0.001 versus WT controls