Fig. 2

Fcγ receptor (FcγR)I,II,III,IV deficiency does not impair the humoral and cellular immune responses against methylated bovine serum albumin (mBSA). a Significantly increased anti-mBSA total immunoglobulin G (IgG), IgG1, and Ig2a titers were measured in the serum of FcγRI,II,III,IV^−/− mice compared with those of wild-type (WT) mice, whereas IgG2b titers were not significantly different (WT, n = 14; FcγRI,II,III,IV^−/−, n = 10; combined from day 7 and day 21). b Accumulation of IgG was present in the knee joints of both WT and FcγRI,II,III,IV^−/− mice 7 days after induction of antigen-induced arthritis as determined by immunolocalization. Original magnification ×400. c The cellular anti-mBSA immune response, as determined by T-cell proliferation, was comparable between WT and FcγRI,II,III,IV^−/− mice. Results are expressed as stimulation index (ratio of stimulation with/without antigen) (n = 4 mice/group). Scatterplots are shown, with horizontal and vertical lines representing mean ± SEM values. ns Not significant. * P < 0.05, ** P < 0.01, *** P < 0.001