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Table 3 Predictors at enrollment of a suboptimal HRQoL at the 36-month follow-up

From: The majority of patients with newly diagnosed juvenile idiopathic arthritis achieve a health-related quality of life that is similar to that of healthy peers: results of the German multicenter inception cohort (ICON)

Predictors PedsQL score of suboptimal HRQoL at the 36-month follow up
Total < 79.3 Physical health < 84.4 Psychosocial health < 73.3
Univariate Multiple Multiple Multiple
Agea 1.01 (0.97–1.05) 1.02 (0.97–1.07) 1.06 (1.02–1.11)** 1.04 (0.99–1.09)
Sexb 1.01 (0.70–1.45)   0.57 (0.38–0.85)**  
SES score 0.97 (0.92–1.03)    
Time between symptom onset and diagnosis 1.01 (1.00–1.03)    
Uveitis 0.86 (0.41–1.66)    
JIA categories
  Persistent oligoarthritis Referent    
  Extended oligoarthritis 1.58 (0.91–2.71)    
  RF-negative polyarthritis 1.10 (0.69–1.73)    
  RF-positive polyarthritis 2.24 (0.63–7.22)    
  Psoriatic arthritis 1.53 (0.66–3.36)    
  Enthesitis-related arthritis 0.95 (0.48–1.80)    
  Systemic-onset JIA 1.22 (0.42–3.12)    
  Undifferentiated arthritis 0.80 (0.34–1.71)    
Disease activity
 cJADAS-10 1.03 (1.00–1.06)*    
 PGA 1.02 (0.96–1.09)    
 Parent’s global 1.19 (1.10–1.29)*** 1.15 (1.05–1.26)**   1.14 (1.03–1.26)**
 Active joint count 1.00 (0.97–1.02)    
Pain
 Numeric rating scale 1.14 (1.07–1.22)***   1.21 (1.13–1.30)***  
Functional ability
 CHAQ 1.74 (1.36–2.23)***    
Psychosocial burden of families
 FaBel total 4.82 (2.96–7.98)*** 3.88 (2.27– 6.72)*** 2.97 (1.78–5.02)*** 3.63 (2.04–6.53)***
  1. *p < 0.05, **p < 0.01, ***p < 0.0001
  2. CHAQ, Childhood Health Assessment Questionnaire; cJADAS-10, clinical Juvenile Arthritis Disease Activity Score; FaBel, Family Burden Questionnaire; HRQoL, health-related quality of life; JIA, juvenile idiopathic arthritis; PedsQL, Pediatric Quality of Life Inventory; PGA, physician’s global assessment of disease activity; RF, rheumatoid factor; SES, socioeconomic status
  3. a Admitted to multivariate analyses to adjust for missing data
  4. b Female referent