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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE

Fig. 3

Average genetic risk score. The average genetic risk score (GRS) was calculated separately for Asian females, Asian males, European females, and European males. Evidence of differences in GRSs was detected between different sexes in both Asian and European populations (Asian females vs males, P = 2.2 × 10− 16; European females vs males, P = 8.295 × 10− 7). The finding that male patients showed a higher disease burden than female patients is consistent with previous results, suggesting that in different populations, the genetic effect size required in male patients is higher than in female patients (***P < 0.001)

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