| |
Men (N = 9513)
|
Women (N = 4600)
|
Total (N = 14,113)
|
Men (N = 43,730)
|
Women (N = 22,052)
|
Total (N = 65,782)
| | |
|
Age at diagnosis (years), mean (SD)
|
65.3 (14.9)
|
71.1 (15.1)
|
67.2 (15.2)
|
64.4 (14.6)
|
70.7 (15.0)
|
66.5 (15.0)
| | |
|
Level of education, N (%)
|
|
≤ 9 years
|
3560 (37.4)
|
2169 (47.2)
| |
15,531 (35.5)
|
9419 (42.7)
| | | |
|
10–12 years
|
4047 (42.6)
|
1655 (36.0)
| |
17,349 (39.7)
|
7699 (34.9)
| | |
|
> 12 years
|
1766 (18.6)
|
690 (15.0)
| |
10,254 (23.5)
|
4509 (20.5)
| | |
|
Comorbidities, total (%)
|
74.4
|
81.2
|
76.6
|
52.8
|
61.3
|
55.7
| | |
|
Comorbidities suggested to increase SU level (%)
|
52.2
|
62.8
|
59.1
|
25.7
|
31.7
|
27.7
| |
|
Psoriasis, PR (95% CI)
|
3.6 (3.3–4.0)
|
4.0 (3.4–4.6)
|
3.7 (3.4–4.1)
|
2.7 (2.5–2.8)
|
2.8 (2.6–3.0)
|
2.7 (2.6–2.8)
|
1.4 (1.3–1.5)
|
< 0.001
|
|
Organ transplantation, PR (95% CI)
|
1.1 (0.9–1.3)
|
1.2 (0.9–1.5)
|
1.1 (1.0–1.3)
|
0.4 (0.3–0.5)
|
0.5 (0.4–0.5)
|
0.4 (0.4–0.5)
|
2.8 (2.3–3.4)
|
< 0.001
|
|
Renal disease, PR (95% CI)
|
12.2 (11.5–12.9)
|
11.1 (10.1–12.1)
|
11.8 (11.3–12.4)
|
5.1 (4.9–5.3)
|
3.4 (3.2–3.6)
|
4.5 (4.4–4.7)
|
2.6 (2.5–2.8)
|
< 0.001
|
|
Use of diuretics, PR (95% CI)
|
39.1 (37.8–40.4)
|
53.4 (51.3–55.5)
|
43.7 (42.7–44.8)
|
15.8 (15.5–16.2)
|
24.3 (23.6–25.0)
|
18.7 (18.4–19.0)
|
2.3 (2.3–2.4)
|
< 0.001
|
|
Obesity, PR (95% CI)
|
9.5 (8.9–10.1)
|
12.2 (11.2–13.2)
|
10.4 (10.0–11.0)
|
3.5 (3.3–3.7)
|
4.8 (4.5–5.1)
|
3.9 (3.8–4.1)
|
2.6 (2.5–2.8)
|
< 0.001
|
|
Alcoholism
|
5.1 (4.6–5.5)
|
1.8 (1.5–2.2)
|
4.0 (3.7–4.3)
|
2.9 (2.7–3.1)
|
0.9 (0.8–1.1)
|
2.2 (2.1–2.3)
|
1.8 (1.6–2.0)
|
< 0.001
|
|
Other comorbidities (%)
|
69.3
|
76.9
|
71.8
|
48.4
|
57.3
|
51.3
| | |
|
Diabetes, PR (95% CI)
|
14.9 (14.1–15.7)
|
18.3 (17.1–19.6)
|
16.0 (15.4–16.7)
|
9.5 (9.2–9.8)
|
8.6 (8.2–9.0)
|
9.2 (9.0–9.4)
|
1.7 (1.7–1.8)
|
< 0.001
|
|
Hypertension, PR (95% CI)
|
64.5 (62.9–66.1)
|
72.3 (69.9–74.8)
|
67.0 (65.7–68.4)
|
41.4 (40.8–42.0)
|
50.2 (49.3–51.1)
|
44.3 (43.8–44.9)
|
1.5 (1.5–1.6)
|
< 0.001
|
|
Coronary heart disease, PR (95% CI)
|
19.5 (18.6–20.4)
|
18.2 (17.0–19.5)
|
19.1 (18.4–19.8)
|
13.7 (13.3–14.0)
|
11.8 (11.4–12.3)
|
13.0 (12.8–13.3)
|
1.5 (1.4–1.5)
|
< 0.001
|
|
Congestive heart failure, PR (95% CI)
|
16.2 (16.1–17.8)
|
21.4 (20.1–22.8)
|
18.4 (17.7–19.1)
|
6.5 (6.3–6.8)
|
7.7 (7.3–8.1)
|
6.9 (6.7–7.1)
|
2.7 (2.5–2.8)
|
< 0.001
|
|
Atrial fibrillation, PR (95% CI)
|
18.6 (17.7–19.5)
|
19.0 (17.8–20.3)
|
18.7 (18.0–19.5)
|
7.5 (7.3–7.8)
|
7.7 (7.3–8.1)
|
7.6 (7.4–7.8)
|
2.5 (2.4–2.6)
|
< 0.001
|
|
Stroke, PR (95% CI)
|
8.3 (7.7–8.9)
|
9.4 (8.6–10.3)
|
8.7 (8.2–9.2)
|
6.9 (6.6–7.1)
|
7.9 (7.5–8.3)
|
7.2 (7.0–7.4)
|
1.2 (1.1–1.3)
|
< 0.001
|
|
Thromboembolism, PR (95% CI)
|
9.7 (9.1–10.4)
|
13.6 (12.6–14.7)
|
11.0 (10.5–11.6)
|
5.4 (5.2–5.6)
|
7.3 (7.0–7.7)
|
6.0 (5.8–6.2)
|
1.8 (1.7–1.9)
|
< 0.001
|
|
Peripheral vascular disease, PR (95% CI)
|
4.5 (4.1–5.0)
|
5.5 (4.8–6.2)
|
4.8 (4.5–5.2)
|
2.2 (2.0–2.3)
|
2.6 (2.4–2.8)
|
2.3 (2.2–2.4)
|
2.1 (1.9–2.3)
|
< 0.001
|
|
Chronic obstructive pulmonary disease, PR (95% CI)
|
4.9 (4.5–5.4)
|
6.5 (5.8–7.3)
|
5.5 (5.1–5.9)
|
2.3 (2.1–2.4)
|
3.2 (3.0–3.4)
|
2.6 (2.5–2.7)
|
2.1 (1.9–2.3)
|
< 0.001
|
