Fig. 2

Regional association plots from the meta-analysis of the two cohorts for all five genome-wide significant loci: -log10 (p values) for both directly genotyped and imputed single nucleotide polymorphisms (SNPs) are plotted as a function of genomic position (NCBI Build 37). The purple diamond indicates the lead SNP at each locus; the remaining markers are colored based on the LD (r [2]) in relation to the lead SNP. Underlying the image, the estimated recombination rate (cM/Mb) for the CEU panel from 1000 Genomes is depicted