Skip to main content

Advertisement

Table 1 Novel SNPs for SLE risk showing genome-wide significance (p < 5 × 10− 8) following meta-analysis of Spain and European ancestry cohorts

From: Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus

      European Spain Meta-analysis
Locus Chr SNP bp RA OR (CI 95%) p value OR (CI 95%) p value OR (CI 95%) p value
SMYD3 1 rs1780813 246,444,082 C 0.53 (0.40–0.69) 8.36 × 10−7 0.61 (0.37–0.98) 0.013 0.55 (0.31–0.79) 3.5 × 10−8
ST8SIA4 5 rs55849330 100,184,647 A 1.16 (1.10–.123) 8.4 × 10−7 1.14 (1.01–1.30) 0.019 1.16 (1.11–1.21) 4.9 × 10−8
LAT2 7 rs150518861 73,566,677 A 1.63 (1.34–1.99) 0.0000015 1.77 (1.23–2.56) 0.0074 1.66 (1.49–1.84) 4.1 × 10−8
ARHGAP27 17 rs114038709 43,456,728 T 1.15 (1.08–1.22) 0.0000012 1.20 (1.07–1.35) 0.0088 1.16 (1.11–1.22) 3.7 × 10−8
GRB2 17 rs36023980 73,341,284 C 1.18(1.11–1.25) 0.0000015 1.23 (1.08–1.40) 0.00039 1.18 (1.13–1.24) 4.7 × 10−9
  1. OR are shown for the minor allele for all five associated polymorphisms
  2. Locus closest gene, Chr chromosome, SNP single nucleotide polymorphism, bp base pair, RA risk allele, OR odds ratio