Table 1 Novel SNPs for SLE risk showing genome-wide significance (p < 5 × 10− 8) following meta-analysis of Spain and European ancestry cohorts
European | Spain | Meta-analysis | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Locus | Chr | SNP | bp | RA | OR (CI 95%) | p value | OR (CI 95%) | p value | OR (CI 95%) | p value |
SMYD3 | 1 | rs1780813 | 246,444,082 | C | 0.53 (0.40–0.69) | 8.36 × 10−7 | 0.61 (0.37–0.98) | 0.013 | 0.55 (0.31–0.79) | 3.5 × 10−8 |
ST8SIA4 | 5 | rs55849330 | 100,184,647 | A | 1.16 (1.10–.123) | 8.4 × 10−7 | 1.14 (1.01–1.30) | 0.019 | 1.16 (1.11–1.21) | 4.9 × 10−8 |
LAT2 | 7 | rs150518861 | 73,566,677 | A | 1.63 (1.34–1.99) | 0.0000015 | 1.77 (1.23–2.56) | 0.0074 | 1.66 (1.49–1.84) | 4.1 × 10−8 |
ARHGAP27 | 17 | rs114038709 | 43,456,728 | T | 1.15 (1.08–1.22) | 0.0000012 | 1.20 (1.07–1.35) | 0.0088 | 1.16 (1.11–1.22) | 3.7 × 10−8 |
GRB2 | 17 | rs36023980 | 73,341,284 | C | 1.18(1.11–1.25) | 0.0000015 | 1.23 (1.08–1.40) | 0.00039 | 1.18 (1.13–1.24) | 4.7 × 10−9 |