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Table 2 Biological pathways significantly associated with SLE risk

From: Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus

Biological pathway N genes Spain cohort p value European cohort p value Combined p value Adjusted p value
B cell receptor signaling 75 0.016 2.05 × 10−6 5.28 × 10− 6 0.0057
CTLA4 co-stimulatory signal during T-cell activation 21 0.0014 0.0016 3.06 × 10−5 0.033
Interleukin-4 signaling 11 0.00029 0.01 3.97 × 10−5 0.043
Cell surface interactions at the vascular wall 91 0.0057 0.0006 4.63 × 10−5 0.049
  1. Biological pathways significantly associated with systemic lupus erythematosus (SLE) after meta-analysis of the Spain and Caucasian European cohorts. P values for each cohort were estimated using PASCAL after removing the previously known risk loci for SLE
  2. N genes number of genes in the pathway