Table 2 Biological pathways significantly associated with SLE risk
Biological pathway | N genes | Spain cohort p value | European cohort p value | Combined p value | Adjusted p value |
|---|---|---|---|---|---|
B cell receptor signaling | 75 | 0.016 | 2.05 × 10−6 | 5.28 × 10− 6 | 0.0057 |
CTLA4 co-stimulatory signal during T-cell activation | 21 | 0.0014 | 0.0016 | 3.06 × 10−5 | 0.033 |
Interleukin-4 signaling | 11 | 0.00029 | 0.01 | 3.97 × 10−5 | 0.043 |
Cell surface interactions at the vascular wall | 91 | 0.0057 | 0.0006 | 4.63 × 10−5 | 0.049 |