Table 3 Physiological and quality of life outcomes

ACh CVC

0.14 ± 0.06

0.19 ± 0.08

0.20 ± 0.11

0.26 ± 0.1

0.20 ± 0.08

0.15 ± 0.08

ACh CVC_max

1.28 ± 0.78

1.56 ± 0.88*

1.49 ± 0.99

1.26 ± 0.52

1.40 ± 0.78

0.82 ± 0.47

ACh T_max (sec)

159.4 ± 83

104.1 ± 71.8

172 ± 57.9

119.4 ± 82.9

127.9 ± 51.1

149.9 ± 70.3

SNP CVC

0.15 ± 0.08

0.24 ± 0.14

0.21 ± 0.11

0.25 ± 0.08

0.20 ± 0.09

0.20 ± 0.1

SNP CVC_max

1.73 ± 2.01

1.88 ± 1.52

1.61 ± 1.21

2.38 ± 1.8

1.70 ± 1.3

1.40 ± 0.56

SNP T_max (sec)

161.2 ± 88.5

131.3 ± 77.5

167.4 ± 66.3

138.8 ± 80.5

165.5 ± 56.5

166.9 ± 76.4

ΔTcpO2

2.5 ± 4.0

9.2 ± 12.1

1.56 ± 4.8

1.56 ± 9.5

1.39 ± 3.4

0.89 ± 2.6

ΔTcpO2_max

11.5 ± 3.9

18.4 ± 16.5

11.7 ± 3.6

13.6 ± 9.6

9.44 ± 7.7

8.0 ± 7.0

V̇O_2peak (ml kg^− 1 min^− 1)

17.7 ± 4.7

21.9 ± 7.1*

14.6 ± 2.9

18.5 ± 2.8*

14.3 ± 6.9

14.7 ± 6.2

Life satisfaction

6.5 ± 1.6

8.1 ± 1.7***

8.4 ± 1.4*

8.8 ± 1.1***

7.5 ± 1.6

4.9 ± 1.5

Mobility

2.4 ± 1.0

2.3 ± 0.8

1.9 ± 0.9

1.7 ± 1.0

1.9 ± 0.9

2.3 ± 1.2

Self-care

1.1 ± 0.3

1.1 ± 0.3

1.2 ± 0.4

1.0 ± 0.0

1.4 ± 0.9

1.7 ± 1.4

Usual activity

2.3 ± 1.3

1.9 ± 1.1

1.9 ± 1.0

1.6 ± 0.7

1.8 ± 1.0

2.4 ± 1.2

Pain/ discomfort

2.4 ± 1.0

2.3 ± 1.1

2.8 ± 1.1

1.8 ± 0.9

2.4 ± 0.7

2.8 ± 1.2

Anxiety/ depression

1.7 ± 0.8

1.5 ± 0.7

1.6 ± 0.7

1.2 ± 0.4

1.6 ± 0.7

1.9 ± 1.4

Raynaud’s pain

2.4 ± 1.4

1.8 ± 0.6*

2.6 ± 1.5

1.9 ± 1.2*

2.4 ± 0.9

3.1 ± 1.1