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Table 1 Characteristics of the included articles (n = 14)

From: Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies

Article

Country

Study setting (study name)

Age (years)

Gender

Ethnicity

Years of follow-up

Ascertainment of exposure

Ascertainment of gout diagnosis

Prior et al. 1987 [10]

New Zealand and Tokelau

Population based

≥ 15 at baseline, ≥ 18 at first

follow-up

Men and women included, but numbers not specified

100% Tokelauan

Up to 14

Hypertension: measurement of systolic and diastolic blood pressure

History of ≥ 2 episodes of podagra with redness and swelling of first metatarsophalangeal joint

Roubenoff et al. (1991) [11]a

USA

Population based

(medical students)

(John Hopkins precursor study)

Median 22

Men: 1216 (91%); women: 121 (9%)

White: 1301 (97%); non-white: 36 (3%)

40

Hypertension: self-reported SBP > 160 mmHg or DBP > 95 mmHg on two questionnaires or self-reported anti-hypertensive medication use

Self-report followed by medical chart review

Hochberg et al. (1995) [12]a

USA

Population based (medical students)

(John Hopkins precursor study)

White: mean 26.1, SD 1.8; black: mean 29.0, SD 3.8

Men: 923 (100%)

White: 571 (62%); black: 352 (38%)

26–34; mean 29

Hypertension: self-reported SBP > 160 mmHg or DBP > 95 mmHg on two questionnaires or self-reported anti-hypertensive medication use

Self-report plus one of: history of MSU crystals or documented tophus or use of colchicine, probenecid or allopurinol

Grodzicki et al. (1997) [13]a

UK

Primary care

(general practice hypertension study)

18–65

Men: 1060 (50%); women: 1068 (50%)

Not reported

Average 8

Hypertension: not reported

Diuretic use: not reported

Diagnosed by GP

Choi et al. (2005) [14]a

USA

Population based (male healthcare professionals)

(health professionals follow-up study)

40–75,

mean 54

Men: 47,150 (100%)

91% white

12

Obesity: self-reportedHypertension: self-reported physician-diagnosed hypertension

Diuretic use: self-reported

Self-report followed by ACR criteria (≥ 6/11 for diagnosis of gout)

Bhole et al. (2010) [15]a

USA

Population based

(Framington heart study)

Men: mean 46, SD 9; women: mean 47, SD 9

Men: 1951 (44%); women: 2476 (56%)

Not reported

52; median 28

Obesity: measured height and weight, BMI calculatedHypertension: average of two readings SBP ≥ 140 mmHg or DBP ≥ 90 mmHgDiuretic use: self-reported

Clinical diagnosis at any follow-up study examination

McAdams DeMarco et al. (2011) [16]a

USA

Population based

(CLUE II study)

13–87 at baseline, ≥ 24 at first follow-up

Men: 6100 (39%); women: 9433 (61%)

White: 15,533 (100%)

18

Obesity: self-reported

Self-report

Maynard et al. (2012) [17]a

USA

Population based

(ARIC)

45–64

Women: 6263 (100%)

White: 4676 (75%); black: 1587 (25%)

9

Obesity: self-reported

Self-report

Chen et al.

(2012) [18]a

Taiwan

Population based

(health insurance database)

Men: mean 46, SD 9; women: mean 47, SD 9

Men: 60,181 (45%); women: 72,375 (55%)

Median 7.31

Hypertension: record linkage

Record linkage: diagnostic code of gout from ICD-9 + 2× prescriptions of colchicine + prescription of urate-lowering drugs

McAdams-DeMarco et al. (2012) [25]a

USA

Population based

(ARIC)

45–64; mean 54, SD 5.7

Men: 4709 (43%); women: 6163 (57%)

White: 8538 (79%); black: 2334 (21%)

9

Hypertension: self-report of anti-hypertension medications or measured high blood pressure

Self-report

McAdams DeMarco et al. (2012) [20]

USA

Population based

(ARIC)

45–64; mean 54, SD 5.7

Men: 2445 (42%); women: 3344 (58%)

White: 3998 (69%); black: 1791 (31%)

9

Diuretic use: self-report

Self-report

Wilson et al. (2014) [21]

USA

Population based

(health insurance database)

18–89

Men: 1449 (48%); women: 1584 (52%)

Up to 12

Diuretics: record linkage, chlorthalidone vs hydrochlorothiazide

Record linkage: ICD-9 for gout or allopurinol, febuxostat, colchicine, probenecid

Pan et al. (2015) [22]a

Singapore

Population based

(Singapore Chinese health study)

Hyp. 61.3 (median);

no Hyp. 59.3 (median)

Hyp. men:

4403 (40.7%);

no Hyp. men: 7982 (40.4)

12

Hypertension: self-report at recruitment interview

Self-report and clinical verification

Burke et al. (2016) [23]a

USA

Population based

(ARIC)

≥ 65

No gout (n = 6535): men 43.4%;

gout (n = 230): men 52.2%

White: 100%

25

Hypertension: SBP ≥ 140 mmHg or DBP ≥ 90 mmHg, or use of a medication to treat hypertension

Diuretic use: self-report of medication use

Self-report

  1. ARIC Atherosclerosis Risk In Communities, ACR American College of Rheumatology, BMI body mass index, CLUE (Give us a Clue to Cancer) II study, DBP diastolic blood pressure, GP general practitioner, Hyp. hypertension, ICD-9 International Classification of Diseases, ninth revision, MSU monosodium urate, SBP systolic blood pressure, SD standard deviation
  2. aIncluded in meta-analysis (n = 7)