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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus

Fig. 3

Mir-29b expression was upregulated in systemic lupus erythematosus (SLE) and correlated with clinicopathological variables in patients with SLE. a Expression of miR-29b in peripheral blood mononuclear cells (PBMCs) from 42 patients with SLE and 35 healthy controls (HC) compared using the unpaired Student’s t test. b-d Correlation between expression of circIBTK and Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score, anti-dsDNA titer or complement C3 level analyzed with Spearman’s analysis. e miR-29b expressions in eight patients who achieved significant clinical improvement after systematic treatment; data were compared using the paired Student’s t test. f ROC curve of relative miR-29b expressions for differentiating the 42 patients with SLE from 35 HC. Results are represented as mean ± SD. **P < 0.01, ***P < 0.001

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