Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis

Table 2 Bone microstructure in patients with nonradiographic axial spondyloarthritis assessed by high-resolution peripheral quantitative computed tomography

	axSpA (n = 101)	Control subjects (n = 50)	p Value
Bone geometry
Total bone area, mm²	334 (108)	326 (116)	0.700
Ct. area, mm²	60 (20)	65 (23)	0.022
Tb. area, mm²	265 (78)	254 (83)	0.374
Volumetric bone mineral density
Total BMD, HA/cm³	313 (70)	334 (61)	0.042
Ct. BMD, HA/cm³	823 (66)	846 (78)	0.007
Tb. BMD, HA/cm³	174 (44)	183 (68)	0.376
Tb. meta BMD, HA/cm³	234 (43)	243 (61)	0.310
Tb. inn BMD, HA/cm³	133 (47)	141 (72)	0.491
Bone microstructure
BV/TV, %	14.5 (3.7)	15.2 (5.7)	0.383
Tb. N, mm⁻¹	2.08 (0.31)	2.11 (0.42)	0.799
Tb. Th, μm	70 (15)	72 (17)	0.486
Tb. Sp, μm	417 (83)	410 (104)	0.602
Inhomogeneity, μm	172 (44)	169 (47)	0.828
Ct. Th, μm	767 (190)	840 (160)	0.006
Ct. Po, %	2.4 (1.66)	2.2 (1.57)	0.685

Abbreviations: axSpA Axial spondyloarthritis, Ct. Cortical, Tb. Trabecular, Tb. meta BMD Peripheral trabecular density adjacent to cortex, Tb. inn BMD Central medullary trabecular density, BV/TV Trabecular bone volume, Th Thickness, Sp Separation, Po Porosity
Bone geometry, microstructure, and volumetric bone mineral density (BMD) determined by high-resolution peripheral quantitative computed tomography at the ultradistal radius. Results are median (interquartile range)
Bold indicates significant differences (p < 0.05)

ISSN: 1478-6362