Table 2 Univariable and multivariable analysis of predictors of MTX non-response in all subjects and excluding those in remission at baseline

 Female sex

1.13 (0.87, 1.46)

0.37

1.20 (0.90, 1.59)

0.22

 Age (years)

0.99 (0.98, 1.00)

0.06

0.99 (0.98, 1.00)

0.04

 BMI (kg/m²)

1.02 (1.00, 1.05)

0.04

1.04 (1.02, 1.06)

< 0.01

1.05 (1.02, 1.08)

< 0.01

 Smoking: never

ref

ref

ref

ref

 Smoking: former

1.20 (0.91, 1.59)

0.19

1.23 (0.91, 1.65)

0.18

 Smoking: current

1.78 (1.28, 2.48)

< 0.01

1.74 (1.22, 2.48)

< 0.01

 Alcohol consumption: current

1.14 (0.87, 1.49)

0.34

1.13 (0.85, 1.51)

0.40

 Alcohol consumption: (units/fortnight)

1.01 (1.00, 1.02)

0.08

1.01 (1.00, 1.02)

0.21

 Coffee/tea consumption: (cups/day)

1.03 (0.98, 1.09)

0.20

1.04 (0.99, 1.10)

0.12

 IMD score (units)

1.01 (1.00, 1.02)

0.02

1.01 (1.00, 1.02)

0.05

 Symptom duration (months)

1.00 (1.00, 1.00)

< 0.01

1.00 (1.00, 1.01)

< 0.01

 RF positive

0.66 (0.50, 0.88)

< 0.01

0.62 (0.45, 0.86)

< 0.01

0.57 (0.42, 0.76)

< 0.01

0.52 (0.37, 0.73)

< 0.01

 Satisfied the 1987 ACR criteria

0.59 (0.43, 0.83)

< 0.01

0.66 (0.46, 0.94)

0.02

 HAQ score (units)

0.76 (0.64, 0.90)

< 0.01

1.64 (1.25, 2.15)

< 0.01

0.92 (0.77, 1.11)

0.39

 Co-morbidities: 0

ref

ref

ref

ref

 Co-morbidities: 1

1.30 (0.97, 1.75)

0.08

1.45 (1.06, 2.00)

0.02

 Co-morbidities: 2+

1.29 (0.96, 1.75)

0.09

1.50 (1.08, 2.07)

0.01

 Creatinine (mg/dl)

1.01 (1.00, 1.01)

0.10

1.01 (1.00, 1.01)

0.18

 Morning stiffness (minutes)

1.00 (1.00, 1.00)

0.01

1.00 (1.00, 1.00)

0.18

 TJC28 (joints)

0.94 (0.92, 0.96)

< 0.01

1.06 (1.02, 1.10)

< 0.01

0.96 (0.95, 0.98)

< 0.01

 SJC28 (joints)

0.92 (0.90, 0.94)

< 0.01

0.94 (0.92, 0.96)

< 0.01

 CRP (mg/l)

0.98 (0.97, 0.99)

< 0.01

0.99 (0.98, 0.99)

< 0.01

 Patient VAS (mm)

0.98 (0.97, 0.99)

< 0.01

0.99 (0.98, 0.99)

< 0.01

 DAS28-CRP (units)

0.54 (0.48, 0.60)

< 0.01

0.29 (0.23, 0.39)

< 0.01

0.63 (0.55, 0.71)

< 0.01

0.49 (0.41, 0.58)

< 0.01

 Pain VAS (mm)

0.99 (0.99, 1.00)

< 0.01

1.00 (0.99, 1.00)

0.26

 Fatigue VAS (mm)

1.00 (0.99, 1.00)

0.29

1.00 (1.00, 1.01)

0.21

 Oral or intramuscular steroids: current/recent

0.96 (0.75, 1.24)

0.76

0.97 (0.74, 1.27)

0.82

 NSAIDs: current

1.02 (0.78, 1.32)

0.90

1.08 (0.82, 1.43)

0.58

 csDMARDs: current

1.31 (0.96, 1.79)

0.09

1.37 (0.99, 1.91)

0.06

 csDMARDs: ever

1.43 (1.07, 1.91)

0.02

1.50 (1.11, 2.04)

0.01

 MTX starting dose (mg/week)

0.97 (0.94, 1.02)

0.22

0.98 (0.94, 1.02)

0.30

 HADS Anxiety (units)

1.02 (0.99, 1.05)

0.21

1.07 (1.03, 1.12)

< 0.01

1.04 (1.01, 1.07)

0.01

1.11 (1.07, 1.15)

< 0.01

 HADS Depression (units)

0.98 (0.95, 1.01)

0.19

1.01 (0.98, 1.05)

0.57

 BMQ medication necessity (units)

0.98 (0.94, 1.01)

0.23

0.99 (0.95, 1.03)

0.50

 BMQ medication concerns (units)

1.03 (0.99, 1.06)

0.14

1.03 (0.99, 1.07)

0.14

 BMQ necessity-concerns (units)

0.98 (0.95, 1.00)

0.08

0.98 (0.95, 1.01)

0.16

 IPQ negative illness representation

0.88 (0.68, 1.14)

0.33

1.14 (0.86, 1.51)

0.37