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Table 2 Univariable and multivariable analysis of predictors of MTX non-response in all subjects and excluding those in remission at baseline

From: Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS)

Characteristic All subjects Excluding those in remission
  Univariable Stepwise multivariable n = 833, AUC = 0.77 (95% CI (0.73, 0.80)) Univariable Stepwise multivariable n = 700, AUC = 0.72 (95% CI (0.68, 0.76))
OR (95% CI) p OR (95% CI) p OR (95% CI) p OR (95% CI) p
Demographic and lifestyle factors
 Female sex 1.13 (0.87, 1.46) 0.37    1.20 (0.90, 1.59) 0.22   
 Age (years) 0.99 (0.98, 1.00) 0.06    0.99 (0.98, 1.00) 0.04   
 BMI (kg/m2) 1.02 (1.00, 1.05) 0.04    1.04 (1.02, 1.06) < 0.01 1.05 (1.02, 1.08) < 0.01
 Smoking: never ref ref    ref ref   
 Smoking: former 1.20 (0.91, 1.59) 0.19    1.23 (0.91, 1.65) 0.18   
 Smoking: current 1.78 (1.28, 2.48) < 0.01    1.74 (1.22, 2.48) < 0.01   
 Alcohol consumption: current 1.14 (0.87, 1.49) 0.34    1.13 (0.85, 1.51) 0.40   
 Alcohol consumption: (units/fortnight) 1.01 (1.00, 1.02) 0.08    1.01 (1.00, 1.02) 0.21   
 Coffee/tea consumption: (cups/day) 1.03 (0.98, 1.09) 0.20    1.04 (0.99, 1.10) 0.12   
 IMD score (units) 1.01 (1.00, 1.02) 0.02    1.01 (1.00, 1.02) 0.05   
Disease-specific factors
 Symptom duration (months) 1.00 (1.00, 1.00) < 0.01    1.00 (1.00, 1.01) < 0.01   
 RF positive 0.66 (0.50, 0.88) < 0.01 0.62 (0.45, 0.86) < 0.01 0.57 (0.42, 0.76) < 0.01 0.52 (0.37, 0.73) < 0.01
 Satisfied the 1987 ACR criteria 0.59 (0.43, 0.83) < 0.01    0.66 (0.46, 0.94) 0.02   
 HAQ score (units) 0.76 (0.64, 0.90) < 0.01 1.64 (1.25, 2.15) < 0.01 0.92 (0.77, 1.11) 0.39   
 Co-morbidities: 0 ref ref    ref ref   
 Co-morbidities: 1 1.30 (0.97, 1.75) 0.08    1.45 (1.06, 2.00) 0.02   
 Co-morbidities: 2+ 1.29 (0.96, 1.75) 0.09    1.50 (1.08, 2.07) 0.01   
 Creatinine (mg/dl) 1.01 (1.00, 1.01) 0.10    1.01 (1.00, 1.01) 0.18   
Disease activity
 Morning stiffness (minutes) 1.00 (1.00, 1.00) 0.01    1.00 (1.00, 1.00) 0.18   
 TJC28 (joints) 0.94 (0.92, 0.96) < 0.01 1.06 (1.02, 1.10) < 0.01 0.96 (0.95, 0.98) < 0.01   
 SJC28 (joints) 0.92 (0.90, 0.94) < 0.01    0.94 (0.92, 0.96) < 0.01   
 CRP (mg/l) 0.98 (0.97, 0.99) < 0.01    0.99 (0.98, 0.99) < 0.01   
 Patient VAS (mm) 0.98 (0.97, 0.99) < 0.01    0.99 (0.98, 0.99) < 0.01   
 DAS28-CRP (units) 0.54 (0.48, 0.60) < 0.01 0.29 (0.23, 0.39) < 0.01 0.63 (0.55, 0.71) < 0.01 0.49 (0.41, 0.58) < 0.01
 Pain VAS (mm) 0.99 (0.99, 1.00) < 0.01    1.00 (0.99, 1.00) 0.26   
 Fatigue VAS (mm) 1.00 (0.99, 1.00) 0.29    1.00 (1.00, 1.01) 0.21   
Medication
 Oral or intramuscular steroids: current/recent 0.96 (0.75, 1.24) 0.76    0.97 (0.74, 1.27) 0.82   
 NSAIDs: current 1.02 (0.78, 1.32) 0.90    1.08 (0.82, 1.43) 0.58   
 csDMARDs: current 1.31 (0.96, 1.79) 0.09    1.37 (0.99, 1.91) 0.06   
 csDMARDs: ever 1.43 (1.07, 1.91) 0.02    1.50 (1.11, 2.04) 0.01   
 MTX starting dose (mg/week) 0.97 (0.94, 1.02) 0.22    0.98 (0.94, 1.02) 0.30   
Psychosocial factors
 HADS Anxiety (units) 1.02 (0.99, 1.05) 0.21 1.07 (1.03, 1.12) < 0.01 1.04 (1.01, 1.07) 0.01 1.11 (1.07, 1.15) < 0.01
 HADS Depression (units) 0.98 (0.95, 1.01) 0.19    1.01 (0.98, 1.05) 0.57   
 BMQ medication necessity (units) 0.98 (0.94, 1.01) 0.23    0.99 (0.95, 1.03) 0.50   
 BMQ medication concerns (units) 1.03 (0.99, 1.06) 0.14    1.03 (0.99, 1.07) 0.14   
 BMQ necessity-concerns (units) 0.98 (0.95, 1.00) 0.08    0.98 (0.95, 1.01) 0.16   
 IPQ negative illness representation 0.88 (0.68, 1.14) 0.33    1.14 (0.86, 1.51) 0.37   
  1. Abbreviations: BMI body mass index, IMD Index of Multiple Deprivation, RF rheumatoid factor, HAQ Health Assessment Questionnaire, TJC28 tender 28-joint count, SJC28 swollen 28-joint count, CRP C-reactive protein, VAS visual analogue scale, DAS28 Disease Activity Score based on the 28-joint count, NSAIDs non-steroidal anti-inflammatory drugs, csDMARDS conventional synthetic disease-modifying anti-rheumatic drugs, HADS Hospital Anxiety and Depression Scale, BMQ Beliefs about Medicines Questionnaire, IPQ Illness Perception Questionnaire