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Table 1 Baseline characteristics of female and male early diagnosed untreated RA patients and healthy controls

From: Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis patients

  ueRA female
(n = 50)
ueRA male
(n = 22)
P value HC female
(n = 18)
HC male
(n = 13)
Age, yr.a 60.5 (21–78) 56 (28–80) 0.87c 56 (20–72) 55 (27–75)e
Symptom duration, monthsa,b 6 (2–23) 3.9 (1–21) 0.07c   
CRP, mg/La 9 (0.3–180) 10 (2–113) 0.29c   
ESR, mm/houra 28 (5–120) 22.5 (1–85) 0.33c   
SJC66a 11.5 (3–30) 9 (2–18) 0.08c   
TJC68a 13 (2–47) 15.5 (3–26) 0.79c   
SJC28a 9 (2–24) 7 (2–15) 0.15c   
TJC28a 8.5 (0–27) 9 (1–16) 0.93c   
DAS28-CRPa 4.9 (2.7–8.3) 5.2 (3.4–6.4) 0.50c   
DAS28-ESRa 5.3 (2.6–8.7) 5.5 (2.9–6.7) 0.83c   
CDAIa 28.3 (10.1–68.7) 28.0 (10.5–40.6) 0.40c   
ACPA+, n (%)f 42 (84) 17 (77) 0.52d   
RF+, n (%)g 38 (76) 14 (64) 0.40d  
ACPA+ and RF+, n (%)f,g 35 (70) 13 (59) 0.42d  
ACPA- and RF-, n (%)f,g 5 (10) 4 (18) 0.44d  
Smoker (%)h 8 (17) 3 (14) > 0.99d   
  1. ACPA anti-citrullinated protein/peptide antibodies, CDAI clinical disease activity index, CRP C-reactive protein, DAS28 disease activity score in 28 joints, ESR erythrocyte sedimentation rate, HC healthy controls, RF rheumatoid factor, SJC 28/66 swollen joint counts of 28/66, TJC 28/68 tender joint counts of 28/68, ueRA untreated early rheumatoid arthritis
  2. aMedian and range
  3. bRetrospective patient-reported pain in the joints before RA diagnosis
  4. cDifference between ueRA female patients and ueRA male patients, Mann-Whitney U test
  5. dDifference between ueRA female patients and ueRA male patients, Fisher’s exact test
  6. eDifference between HC female age and HC male age, P = 0.53, Mann-Whitney U test
  7. fPatients with ACPA levels ≥20 IU/ml are considered ACPA+
  8. gPatients with RF levels ≥20 IU/ml are considered RF+
  9. hCurrent daily smoker (data available in nfemale = 47, nmale = 22)