Fig. 3
Effects of secukinumab treatment on the articular and extra-articular structural bone changes in patients with psoriatic arthritis. a Comparison of bone erosions in the joints of psoriatic arthritis (PsA) patients using magnetic resonance imaging (MRI, left) and high-resolution peripheral quantitative computed tomography (HR-pQCT, right) at baseline (BL) and after 24 weeks (Wk24) of secukinumab treatment. MRI data represent Psoriatic arthritis MRI scores (PsAMRIS) for erosions, and HR-pQCT data represent erosion volumes. b Comparison of enthesiophytes in the joints of PsA patients using MRI (left) and HR-pQCT (right) at baseline (BL) and after 24 weeks (Wk24) of secukinumab treatment. MRI data represent Psoriatic arthritis MRI scores (PsAMRIS) for proliferations, and HR-pQCT data represent enthesiophyte grades according to size. c Comparison of bone micro-structural data of the distal radius of PsA patients using HR-pQCT at baseline (BL) and after 24 weeks (Wk24) of secukinumab treatment. Cortical and trabecular volumetric bone density (vBMD), cortical thickness, and trabecular numbers are shown. d Comparison of biomechanical properties of radial bones of PsA patients using HR-pQCT measurements at baseline (BL) and after 24 weeks (Wk24) of secukinumab treatment. Data show failure load and bone stiffness based on micro-finite element analysis. Data are presented as median and interquartile ranges. Abbreviations: kN kiloNewton, mgHA/cm3 milligram of hydroxyapatite per cube centimeter, N Newton