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Fig. 5 | Arthritis Research & Therapy

Fig. 5

From: A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

Fig. 5

MCC22 improves grip strength and nest-building behavior. a Grip strength was measured in arthritic K/B.g7 mice or nonarthritic control mice. The K/B.g7 mice were treated with the indicated compounds (MCC22 0.008 μmol/kg/dose and morphine 6.62 μmol/kg/dose). Data were compared using one-way ANOVA with post-hoc Tukey’s test for multiple comparisons and using the C57BL/6 group as the reference group. The values for the arthritic K/B.g7 mice were all significantly lower than that of the nonarthritic C57BL/6 mice (p < 0.0001). b Nest-bedding scores were recorded among groups of arthritic K/B.g7 mice treated with the indicated compounds. Data were compared using one-way ANOVA with post-hoc Tukey’s test for multiple comparisons. In a each point represents one mouse, and in b each point represents one cage of mice. Bars represent mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.00,1 NS not significant. c Representative photographs of arthritic K/B.g7 mice demonstrating a bedding score of 2 for mice treated with vehicle (left) or and a bedding score of 4 for mice treated with MCC22 (right)

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