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Fig. 3 | Arthritis Research & Therapy

Fig. 3

From: NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Fig. 3

Effect of oral treatment with OLT1177 in monosodium urate (MSU)-induced arthritis. a Representative images of joints of saline-injected knee (Saline) and from vehicle-treated and OLT1177 (600 mg/kg)-treated mice. b Mean ± SEM of joint score (n = 20). c H&E-stained histological knee joint sections from vehicle- or OLT1177-treated mice. Original magnification 100 ×. d Mean ± SEM of cell influx (n = 10). eh Mean ± SEM of interleukin (IL)-1β, IL-6, myeloperoxidase (MPO), and chemokine (C-X-C motif) ligand 1 (CXCL1) in synovial tissue lysates from mice subjected to experimental MSU-induced arthritis. n = 10 per group. **** p < 0.0001, *** p < 0.001, ** p < 0.01, * p < 0.05

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