Fig. 4

Effect of posttreatment of oral OLT1177 in monosodium urate-induced arthritis. Total white blood cell (WBC) count (a) and differential counts (b) in mice treated with vehicle or OLT1177 (600 mg/kg) (n = 5). c Mean ± SEM of spontaneous (Spnt) interleukin (IL)-6 levels from whole-blood culture in vehicle- and OLT1177-treated mice. d Mean ± SEM of joint score (n = 20). e–g Mean ± SEM of IL-1β, IL-6, and chemokine (C-X-C motif) ligand 1 (CXCL1) in synovial tissue extracts (n = 10 per group). h Western blot of phospho-c-Jun N-terminal kinase (JNK) and IL-1β (p17 and IL-1β precursor p37) in synovial tissue extracts. Each lane represents a single mouse. **** p < 0.0001, ** p < 0.01, * p < 0.05. SAPK Stress-activated protein kinase