The relationship between ferritin and urate levels and risk of gout

Table 1 Association of ferritin (per 10 ng ml^− 1 increment) with serum urate (mg dl^− 1)

Population	n ^a	β (95% CI)^b	p ^b	β (95% CI)^c	p ^c
NZ European	60	0.011 (− 0.006; 0.027)	0.24	0.009 (− 0.009; 0.027)	0.31
NZ Polynesian	60	0.015 (0.007; 0.023)	1.4E–04	0.014 (0.007; 0.022)	2.5E–04
US	60	0.048 (− 0.006; 0.102)	0.079	0.041 (− 0.015; 0.097)	0.15
JHS (males)	567	0.008 (0.002; 0.014)	9.6E–03	0.007 (0.002; 0.014)	9.3E–03
JHS (females)	693	0.023 (0.015; 0.032)	1.6E–07	0.014 (0.005; 0.022)	1.7E–03
JHS (combined)	1260	0.027 (0.023; 0.033)	1.8E–27	0.009 (0.005; 0.014)	3.2E–05
NHANES III African American (males)	1925	0.010 (0.007; 0.014)	7.2E–09	0.006 (0.003; 0.009)	5.1E–04
NHANES III African American (females)	2430	0.028 (0.027; 0.032)	1.3E–42	0.016 (0.012; 0.020)	1.8E–15
NHANES III African American (combined)	4355	0.029 (0.026; 0.031)	2.0E–97	0.011 (0.008; 0.013)	2.1E–16
NHANES III European (males)	2460	0.006 (0.003; 0.009)	1.0E–04	0.004 (0.001; 0.007)	6.6E–03
NHANES III European (females)	2652	0.019 (0.015; 0.023)	1.3E–22	0.012 (0.008; 0.015)	3.4E–10
NHANES III European (combined)	5112	0.025 (0.023; 0.028)	6.9E–84	0.007 (0.005; 0.009)	5.1E–11
Meta-analyzed data	10,907	0.025 (0.021; 0.028)	9.3E–34	0.009 (0.007; 0.011)	3.9E–32

Beta values represent change in serum urate in mg dl^− 1 per 10 ng ml^− 1 increase in concentration of serum ferritin
CI confidence interval, NZ New Zealand, US United States, JHS Jackson Heart Study, NHANES National Health and Nutrition Examination Survey
^aNumber of nongout (control) individuals
^bUnadjusted
^cAdjusted for age, body mass index, C-reactive protein and number of self-reported Polynesian grandparents in the NZ Polynesian analyses. Combined analyses are additionally adjusted for sex

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