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Table 3 Genes expressed significantly higher in CD8+ T cells of patients with dermatomyositis than in those with polymyositis

From: T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients

Gene symbol

Gene name

AL365357.1

Ribosomal protein S14 pseudogene 2

AL591846.1

Ribosomal protein S14 pseudogene 1

NKG7

Natural killer cell granule protein 7

TGFBR3

Transforming growth factor beta receptor 3

GZMH

Granzyme H

EFHD2

EF-hand domain family member D2

ZEB2

Zinc finger E-box binding homeobox 2

KIAA1671

KIAA1671

SETBP1

SET binding protein 1

FAM118A

Family with sequence similarity 118 member A

ADGRG1

Adhesion G protein-coupled receptor G1

ADRB2

Adrenoceptor beta 2

CACNA2D2

Calcium voltage-gated channel auxiliary subunit alpha2delta 2

PDGFD

Platelet-derived growth factor D

SH3TC1

SH3 domain and tetratricopeptide repeats 1

PRSS23

Serine protease 23

TBKBP1

TBK1 binding protein 1

AC009951.1

 

RAB11FIP5

RAB11 family interacting protein 5

GNAO1

G protein subunit alpha o1

MUC16

Mucin 16, cell surface associated

RP11-107E5.2

 

KIF19

Kinesin family member 19

CST7

Cystatin F

SMAD7

SMAD family member 7

LINC02086

Long intergenic non-protein coding RNA 2086

AC040970.1

Uncharacterized LOC101927963

LLGL2

LLGL2, scribble cell polarity complex component

SYNE1

Spectrin repeat containing nuclear envelope protein 1

RAP1GAP2

RAP1 GTPase activating protein 2

FAM53B

Family with sequence similarity 53 member B

TOGARAM2

TOG array regulator of axonemal microtubules 2

FRMPD3

FERM and PDZ domain containing 3

TBX21

T-box 21

SESN2

Sestrin 2

PAX5

Paired box 5

MIDN

Midnolin

CCL5

C-C motif chemokine ligand 5

SYTL3

Synaptotagmin like 3

GAB3

GRB2 associated binding protein 3

TTC38

Tetratricopeptide repeat domain 38

LDLR

Low density lipoprotein receptor

CCL4

C-C motif chemokine ligand 4

DMWD

DM1 locus, WD repeat containing

CASZ1

Castor zinc finger 1

LAG3

Lymphocyte activating 3

DYRK1B

Dual specificity tyrosine phosphorylation regulated kinase 1B

GPR153

G protein-coupled receptor 153

MATK

Megakaryocyte-associated tyrosine kinase

SH2D2A

SH2 domain containing 2A

RHBDF2

Rhomboid 5 homolog 2

ADGRG5

Adhesion G protein-coupled receptor G5

UBE2Q2P1

Ubiquitin conjugating enzyme E2 Q2 pseudogene 1

GALNT3

Polypeptide N-acetylgalactosaminyltransferase 3

RUNX3

Runt related transcription factor 3

PLA2G16

Phospholipase A2 group XVI

SLC15A4

Solute carrier family 15 member 4

PPP2R2B

Protein phosphatase 2 regulatory subunit beta

RGS9

Regulator of G protein signaling 9

PATL2

PAT1 homolog 2

C1orf21

Chromosome 1 open reading frame 21

S1PR5

Sphingosine-1-phosphate receptor 5

TMCC3

Transmembrane and coiled-coil domain family 3

TLR3

Toll like receptor 3

GLB1L2

Galactosidase beta 1 like 2

PRELID2

PRELI domain containing 2

ADAP1

ArfGAP with dual PH domains 1

TRGJ2

T cell receptor gamma joining 2

DENND3

DENN domain containing 3

SOX13

SRY-box 13

GZMB

Granzyme B

FGFBP2

Fibroblast growth factor binding protein 2

RAP2A

RAP2A, member of RAS oncogene family

FCRL6

Fc receptor like 6

ITGAL

Integrin subunit alpha L

ABHD17A

Abhydrolase domain containing 17A

CHST12

Carbohydrate sulfotransferase 12

NBEAL2

Neurobeachin like 2

ADAM8

ADAM metallopeptidase domain 8

SLC1A7

Solute carrier family 1 member 7

LTBP4

Latent transforming growth factor beta binding protein 4

CRIP1

Cysteine rich protein 1

RNF166

Ring finger protein 166

MXD4

MAX dimerization protein 4

TNFSF9

TNF superfamily member 9

ZNF683

Zinc finger protein 683

CTD-2377D24.8

 

HNRNPLL

Heterogeneous nuclear ribonucleoprotein L like

MPST

mercaptopyruvate sulfurtransferase

ATP1A3

ATPase Na+/K+ transporting subunit alpha 3

IFNLR1

Interferon lambda receptor 1

PTMS

Parathymosin

SLC20A1

Solute carrier family 20 member 1

MVD

Mevalonate diphosphate decarboxylase

SH3RF2

SH3 domain containing ring finger 2

RAPGEF1

Rap guanine nucleotide exchange factor 1

TGFB1

Transforming growth factor beta 1

AL928654.3

 

BHLHE40

Basic helix-loop-helix family member e40

MAPKAPK2

Mitogen-activated protein kinase-activated protein kinase 2

PTPRJ

Protein tyrosine phosphatase, receptor type J

DGKQ

Diacylglycerol kinase theta

MYO3B

Myosin IIIB

DUSP8

Dual specificity phosphatase 8

FLNA

Filamin A

NOP14-AS1

NOP14 antisense RNA 1

ITGB2

Integrin subunit beta 2

GNG2

G protein subunit gamma 2

MSC

Musculin

ARHGAP10

Rho GTPase activating protein 10

DNMBP

Dynamin binding protein

MYO1G

Myosin IG

DDN-AS1

DDN and PRKAG1 antisense RNA 1

SIPA1

Signal-induced proliferation-associated 1

AC093616.1

Anaphase-promoting complex subunit 1-like

CTSW

Cathepsin W

PXN

Paxillin

SSBP3

Single-stranded DNA binding protein 3

SLC2A1

Solute carrier family 2 member 1

MCOLN2

Mucolipin 2

NAA50

N(alpha)-acetyltransferase 50, NatE catalytic subunit

RDH10

Retinol dehydrogenase 10

NFATC2

Nuclear factor of activated T cells 2

KDM4B

Lysine demethylase 4B

GALNT10

Polypeptide N-acetylgalactosaminyltransferase 10

DPY19L1P1

DPY19L1 pseudogene 1

INSIG1

Insulin induced gene 1

PLEKHA2

Pleckstrin homology domain containing A2

PROK2

Prokineticin 2

PTP4A2

Protein tyrosine phosphatase type IVA, member 2

GPR27

G protein-coupled receptor 27

LINC00355

Long intergenic non-protein coding RNA 355

  1. The table demonstrates the genes that overlap between the two analytical stages and have a significantly higher expression in CD8+ T cells of patients with dermatomyositis than in those with polymyositis. A false discovery rate threshold of 5% based on the method of Benjamini-Hochberg was used to identify significant differentially expressed genes