Table 4 Significant Gene Ontology (GO) biological processes in CD8+ T cells of polymyositis and dermatomyositis patients
GO biological process complete | Fold enrichment | p value | FDR |
|---|---|---|---|
Lymphocyte migration (GO:0072676) | 11.50 | 1.05E-04 | 4.19E-02 |
Regulation of T-cell differentiation (GO:0045580) | 10.10 | 4.82E-07 | 2.50E-03 |
Regulation of lymphocyte differentiation (GO:0045619) | 8.31 | 2.24E-06 | 3.88E-03 |
Myeloid leukocyte migration (GO:0097529) | 8.17 | 1.26E-04 | 4.69E-02 |
Response to transforming growth factor beta (GO:0071559) | 6.73 | 1.11E-04 | 4.31E-02 |
Regulation of leukocyte differentiation (GO:1902105) | 5.48 | 2.05E-05 | 1.68E-02 |
Regulation of T cell activation (GO:0050863) | 5.26 | 4.48E-06 | 6.34E-03 |
Leukocyte migration (GO:0050900) | 5.04 | 2.79E-06 | 4.35E-03 |
Positive regulation of GTPase activity (GO:0043547) | 4.42 | 1.10E-05 | 1.15E-02 |
Positive regulation of cell adhesion (GO:0045785) | 4.26 | 3.41E-05 | 2.41E-02 |
Positive regulation of MAPK cascade (GO:0043410) | 3.85 | 1.11E-05 | 1.08E-02 |
Regulation of GTPase activity (GO:0043087) | 3.75 | 5.71E-05 | 3.18E-02 |
Regulation of cell activation (GO:0050865) | 3.54 | 2.88E-05 | 2.24E-02 |
Regulation of leukocyte activation (GO:0002694) | 3.51 | 5.87E-05 | 3.05E-02 |
Transmembrane receptor protein tyrosine kinase signaling pathway (GO:0007169) | 3.47 | 1.21E-04 | 4.61E-02 |
Regulation of MAPK cascade (GO:0043408) | 3.42 | 6.96E-06 | 8.34E-03 |
Regulation of cell adhesion (GO:0030155) | 3.27 | 6.93E-05 | 3.27E-02 |
Enzyme linked receptor protein signaling pathway (GO:0007167) | 3.08 | 7.94E-05 | 3.53E-02 |
Cell migration (GO:0016477) | 2.91 | 3.48E-05 | 2.35E-02 |
Positive regulation of immune system process (GO:0002684) | 2.88 | 9.42E-06 | 1.05E-02 |
Regulation of immune system process (GO:0002682) | 2.75 | 2.77E-07 | 2.16E-03 |
Positive regulation of intracellular signal transduction (GO:1902533) | 2.75 | 4.75E-05 | 2.84E-02 |
Regulation of immune response (GO:0050776) | 2.70 | 3.87E-05 | 2.51E-02 |
Positive regulation of catalytic activity (GO:0043085) | 2.45 | 3.19E-05 | 2.36E-02 |
Immune response (GO:0006955) | 2.41 | 5.32E-06 | 6.91E-03 |
Cell surface receptor signaling pathway (GO:0007166) | 2.31 | 5.02E-07 | 1.95E-03 |
Positive regulation of signal transduction (GO:0009967) | 2.31 | 6.66E-05 | 3.24E-02 |
Positive regulation of molecular function (GO:0044093) | 2.24 | 7.60E-05 | 3.48E-02 |
Regulation of intracellular signal transduction (GO:1902531) | 2.22 | 3.92E-05 | 2.44E-02 |
Immune system process (GO:0002376) | 2.21 | 8.12E-07 | 2.11E-03 |
Regulation of multicellular organismal development (GO:2000026) | 2.15 | 8.34E-05 | 3.61E-02 |
Positive regulation of response to stimulus (GO:0048584) | 2.14 | 1.65E-05 | 1.51E-02 |
Regulation of catalytic activity (GO:0050790) | 2.12 | 1.83E-05 | 1.59E-02 |
Regulation of signal transduction (GO:0009966) | 2.01 | 2.08E-06 | 4.05E-03 |
Regulation of developmental process (GO:0050793) | 2.00 | 5.79E-05 | 3.11E-02 |
Regulation of signaling (GO:0023051) | 2.00 | 5.40E-07 | 1.68E-03 |
Regulation of cell communication (GO:0010646) | 1.99 | 8.44E-07 | 1.88E-03 |
Regulation of response to stimulus (GO:0048583) | 1.91 | 2.14E-07 | 3.33E-03 |
Regulation of multicellular organismal process (GO:0051239) | 1.91 | 6.12E-05 | 3.08E-02 |
Regulation of molecular function (GO:0065009) | 1.84 | 8.55E-05 | 3.60E-02 |
Signaling (GO:0023052) | 1.58 | 5.65E-05 | 3.26E-02 |
Cell communication (GO:0007154) | 1.55 | 9.36E-05 | 3.84E-02 |