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Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus

Fig. 1

Two-dimensional hierarchical cluster analyses of immunophenotypic parameters that are differentially expressed in R and NR prior to treatment when considering all patients (a), etanercept (ETN) alone (b), and adalimumab (ADA) alone (c). Columns represent individual patients and the colour code below the vertical dendrogram indicates responders (Resp.; blue) or non-responders (Non R.; red) and the TNF-blocker used (either ETN (cyan) or ADA (pink)). Rows of the cluster diagram represent immunophenotypic parameters with p values < 0.1. The magnitude of parameter expression is colour coded with red for a relatively increased and blue for a relatively decreased expression. The colour code for the horizontal dendrogram indicates the expression in a particular cell type, such as natural killer (NK) cells (cyan), B cells (green), T cells (raspberry-red), monocytes (mo; orange), granulocytes (gr; blue), and CD3-negative lymphocytes (ly CD3–; white). In total, one million cells were acquired per sample to ensure that even rare cell populations with frequencies around 0.1% could be reliable detected

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Arthritis Research & Therapy

ISSN: 1478-6362

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