Fig. 4
From: T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis
Abatacept alleviates pulmonary hypertension in Fra-2 transgenic mice. a Right ventricular systolic pressure (RVSP) and b right ventricular hypertrophy assessed by the Fulton index. c Representative images of hematoxylin and eosin staining (upper row) and representative images of α-smooth muscle actin (α-SMA) immunohistostaining (lower row) showing a substantial reduction in the percentage of medial wall thickness (d) and a significant reduction in the percentage of distal artery muscularization (e) in Fra-2 mice treated with abatacept (ABA) 1 mg/mL and 10 mg/mL compared with control IgG1-treated mice. Scale bars = 100 μm. A total of 27 mice were used (5 C57BL/6 mice, 6 Fra-2 control IgG1, 8 Fra-2 abatacept 1 mg/mL, and 8 Fra-2 abatacept 10 mg/mL). Values are the median ± IQR. Statistics are from post-hoc Dunnett’s multiple comparison test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001