The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

Table 2 Variables associated with pulse wave velocity on univariable analysis

Variable	Univariable analysis
Variable	R²	Regression coefficient [95% CI]	P value
Age, years	0.183	0.131 [0.053, 0.208]	0.001
Gender	0.004	0.393 [− 1.313, 2.100]	0.645
eGFR, mL/min per 1.73 m²	0.026	− 0.023 [− 0.062, 0.017]	0.252
Urinary albumin-to-creatinine ratio, mg/mmol	0.056	0.019 [−0.003, 0.041]	0.088
Ever smoker	0.017	−0.759 [−2.364, 0.847]	0.347
Presence of diabetes	0.002	0.291 [−1.704, 2.286]	0.771
On statin treatment	0.044	1.208 [−0.383, 2.799]	0.134
Pulse pressure, mm Hg	0.163	0.084 [0.030, 0.137]	0.003
Mean arterial pressure, mm Hg	0.102	0.088 [0.015, 0.161]	0.020
Systolic blood pressure, mm Hg	0.191	0.079 [0.033, 0.124]	0.001
Diastolic blood pressure, mm Hg	0.027	0.056 [−0.039, 0.150]	0.243
CD4⁺CD28^null T-cell proportion (%), per 10% increase	0.182	0.912 [0.368, 1.455]	0.001
C-reactive protein, mg/mL	0.008	−0.234 [− 0.958, 0.490]	0.520
IL-2, pg/mL	0.066	0.007 [0.000, 0.015]	0.065
IFN-γ, pg/mL	0.036	−0.004 [− 0.010, 0.002]	0.179
IL-10, pg/mL	0.025	0.089 [−0.068, 0.245]	0.260
IL-6, pg/mL	0.004	0.002 [−0.007, 0.011]	0.649
TNF-α, pg/mL	0.083	0.015 [0.001, 0.029]	0.039
IL-17, pg/mL	0.015	−0.003 [−0.011, 0.004]	0.389

All variables with a P value of less than 0.1 on univariable analysis were included in the multivariable model shown in Table 3
Abbreviations: CI confidence interval, eGFR estimated glomerular filtration rate, IL interleukin, TNF-α tumour necrosis factor-alpha

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