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Fig. 6 | Arthritis Research & Therapy

Fig. 6

From: Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice

Fig. 6

Tartrate acid phosphatase (TRAP) staining of L4/5 coronal sections. The osteoclasts were obtained by counting the number of TRAP-positive staining cells (N. Trap+). A few TRAP-positive cells (purple; red arrows) were distributed on the surface of the trabecular of the subchondral bone and were rarely detected in the endplate of control (CT) mice. However, the TRAP-positive cells (purple; red arrows) significantly increased in the subchondral bone and were obviously noted in the endplate of ovariectomized (OVX) mice, suggesting osteoclast activity increases after OVX. Data are shown as mean ± SD, n = 6 per group. *p < 0.05; scale bars = 100 μm and 50 μm as indicated. CaEP caudal endplate, CrEP cranial endplate, IVD intervertebral disc

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Arthritis Research & Therapy

ISSN: 1478-6362

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