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Table 2 Characteristics of patients without (n = 418) and with (n = 301) certain diagnosis of axSpA stratified by gender

From: Are gender-specific approaches needed in diagnosing early axial spondyloarthritis? Data from the SPondyloArthritis Caught Early cohort

  No axSpA p value axSpA p value
Male
(N = 129)
Female
(N = 289)
Male
(N = 146)
Female
(N = 155)
Age at CBP onset (years), mean (SD) 29.3 (8.6) 29.4 (8.2) 0.9 27.4 (7.5) 29.5 (7.8) 0.02
Duration of CBP (months), mean (SD) 12.8 (6.9) 13.4 (7.0) 0.5 13.3 (7.1) 13.4 (7.0) 0.5
Alternating buttock pain, n (%) (N = 454a) 23 (43) 100 (59) 0.03 65 (60) 64 (51) 0.2
IBP, n (%) 83 (57) 164 (64) 0.2 123 (84) 129 (84) 1.0
Response to NSAIDs, n (%) 45 (37) 81 (29) 0.1 92 (64) 98 (66) 0.8
Family history of SpA, n (%) 44 (34) 124 (44) 0.1 68 (46) 69 (45) 0.8
Peripheral arthritis, n (%) 15 (12) 25 (9) 0.3 37 (25) 34 (22) 0.5
Heel enthesitis, n (%) 17 (13) 28 (10) 0.3 46 (31) 51 (33) 0.7
Dactylitis, n (%) 3 (2) 4 (1) 0.5 16 (11) 16 (10) 0.9
Uveitis, n (%) 7 (5) 12 (4) 0.6 19 (13) 20 (13) 1.0
Psoriasis, n (%) 6 (5) 23 (8) 0.2 22 (15) 37 (24) 0.051
IBD, n (%) 11 (8) 15 (5) 0.2 10 (7) 12 (8) 0.8
HLA-B27+, n (%) 43 (34) 66 (23) 0.02 114 (80) 92 (60) < 0.001
Elevated CRP/ESR, n (%) 21 (16) 61 (21) 0.2 71 (49) 64 (42) 0.2
SpA features without imaging or HLA-B27, mean (SD) 2.4 (0.1) 2.1 (0.1) 0.3 3.5 (1.7) 3.5 (1.6) 1.0
MRI-SIJ+/X-SIJ, n (%) 7 (5) 19 (6) 0.6 65 (44) 68 (44) 0.9
MRI-SIJ/X-SIJ+, n (%) 2 (1) 4 (1) 0.9 5 (3) 5 (3) 0.9
MRI-SIJ+/X-SIJ+, n (%) 5 (4) 0 (0) 0.01 44 (30) 26 (17) 0.006
Any positive imaging,b n (%) 14 (10) 23 (7) 0.3 114 (78) 99 (64) 0.007
Number of syndesmophytes, mean (SD) (N = 182a) n/a n/a 0.1 (0.4) 0.0 (0.1) 0.5
Patients with syndesmophytes, n (%) (N = 182a) n/a n/a 7/83 (8) 1/99 (1) 0.02
Current smokers, n (%) 33 (28) 54 (19) 0.1 31 (22) 15 (10) 0.02
  1. Modified Stoke ankylosing spondylitis Spine Score available for 182/301 axSpA patients. Bold data indicate significant results
  2. axSpA axial spondyloarthritis, CBP chronic back pain, IBP inflammatory back pain, NSAID non-steroidal anti-inflammatory drug, SpA spondyloarthritis, IBD inflammatory bowel disease, HLA human leukocyte antigen, CRP C-reactive protein, ESR erythrocyte sedimentation rate, MRI-SIJ magnetic resonance imaging of sacroiliac joints, X-SIJ plain radiograph of of sacroiliac joints
  3. aMissing data < 5% unless otherwise indicated
  4. bMRI-SIJ + and/or X-SIJ+