Skip to main content
Fig. 1 | Arthritis Research & Therapy

Fig. 1

From: E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts

Fig. 1

E2F2 affects the incidence and degree of CIA in mice. Arthritis was induced in wild-type (WT), E2f2+/−, and E2f2−/− mice and the incidence (a) and clinical pathology (b) of arthritis were evaluated as 0 (no swelling) to 4 (strong swelling) once per day by two independent observers under blinded conditions. All results are presented as the mean ± SEM of three independent experiments performed in triplicate. ***P < 0.001, versus the control. The severity of edema and paw redness was assessed once per day. c The degree of paw thickness was detected both in the fore paws and hind paws. d Hematoxylin and eosin-stained stained slides were scored blind by a trained observer for immune cell invasion. e The depletion of proteoglycans was determined by Safranin O-Fast Green FCF and Toluidine blue staining (100×). The regions of cartilage degeneration, which are light in staining, are marked by arrows

Back to article page

Arthritis Research & Therapy

ISSN: 1478-6362

Contact us