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Fig. 2 | Arthritis Research & Therapy

Fig. 2

From: E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts

Fig. 2

E2F2 is required for production of inflammatory factors in MEFs. MEFs were treated with different concentrations of lipopolysaccharide (LPS) for 12 h. Expression and dose-dependent effects of interleukin (IL)-1α (a), IL-1β (b), and tumor necrosis factor (TNF)-α (c) were detected by qRT-PCR. **P < 0.01, ***P < 0.001, versus vehicle control. Dose-dependent effects of secreted IL-1α (d), IL-1β (e), and TNF-α (f) were detected by ELISA. **P < 0.01, ***P < 0.001, versus vehicle control. IL-1α, IL-1β, and TNF-α in serum of E2f2−/− and wild-type (WT) mice were measured by ELISA (g). **P < 0.01, ***P < 0.001, versus WT

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Arthritis Research & Therapy

ISSN: 1478-6362

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