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Fig. 4 | Arthritis Research & Therapy

Fig. 4

From: CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-κB activation

Fig. 4

CYLD knockdown enhances the production of pro-inflammatory cytokines, MMPs, RANKL, and NF-κB in RA-FLSs. a After CYLD knockdown, we examined pro-inflammatory cytokines, MMPs, and RANKL mRNA expression in FLSs by RT-PCR. b After CYLD knockdown, we evaluated the protein level of pro-inflammatory cytokines, MMPs, and RANKL by ELISA. Data are represented as mean ± SD from 3 independent experiments. *P < 0.05, **P < 0.01

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