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Table 1 Univariate and multivariate analysis between the HLA-B27-positive and HLA-B27-negative groups

From: Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database

  B27 negative B27 postive Univariate analysis Multivariate analysis
n (= 206) Mean ± SD or %a n (= 1029) Mean ± SD or %a p OR 95% CI p
Men 155 75.2 769 74.7 NS    
Family history 22 12 216 22.1 0.002 2.1 1.27–3.49 0.004
Age (years), mean ± SD 206 50,4 ± 12,9 1025 47,9 ± 13 0,012    
Age at onset (years), mean ± SD 204 30.6 ± 12.3 1010 26.2 ± 9.9 < 0.001    
Age at diagnosis (years), mean ± SD 199 39 ± 12.3 1002 33.9 ± 11.5 < 0.001 0.97 0.96–0.98 < 0.001
Disease duration since first symptom (years), mean ± SD 204 19.8 ± 12.8 1013 21.9 ± 13.1 0.038    
Diagnosis delay (years), mean ± SD 198 8.5 ± 9.6 993 7.8 ± 9.2 NS    
Disease duration since diagnosis (years), mean ± SD 199 11.3 ± 9.3 1004 14 ± 10.6 0.001    
Axial manifestations
 Cervicalgia 28 13.6 103 10 NS    
 Lumbalgia 148 71.8 741 72 NS    
 Sacroiliac syndrome 85 41.3 435 42.3 NS    
Peripheral manifestations
 Peripheral arthritis 45 21.8 158 15.4 0.023 0.53 0.32–0.89 0.016
 Coxitis 6 2.9 32 3.1 NS    
 Enthesitis 10 4.9 65 6.3 NS    
 Dactylitis 8 3.9 8 0.8 0.001 0.16 0.05–0.56 0.004
Extra-articular manifestations
 Psoriasis 30 14.6 61 5.9 < 0.001 0.45 0.26–0.78 0.005
 Inflammatory bowel disease 24 11.7 37 3.6 < 0.001 0.22 0.12–0.4 < 0.001
 Urethritis, cervicitis, diarrhea 4 1.9 7 0.7 NS    
 Anterior uveitis 40 19.4 230 22.4 NS    
 Palmoplantar pustulosis 6 2.9 4 0.4 0.002 0.12 0.02–0.64 0.013
 Balanitis 4 1.9 4 0.4 0.022    
 Prostatitis 1 0.5 7 0.7 NS    
BASRI score, mean ± SD 194 7.4 ± 4.1 974 7.2 ± 3.9 NS    
BASDAI score, mean ± SD 206 4.4 ± 2.4 1029 4.1 ± 2.3 0.047    
BASFI score, mean ± SD 206 4.3 ± 2.9 1028 3.8 ± 2.7 0.005 0.94 0.88–1 0.037
ESR (mm/1 h), mean ± SD 174 19 ± 15.98 977 18.3 ± 16.3 NS    
CRP (mg/L), mean ± SD 174 10.2 ± 17.7 975 9.2 ± 13.7 NS    
  1. BASDAI Bath Ankylosing Spondylitis Disease Activity Index, BASFI Bath Ankylosing Spondylitis Functional Index, BASRI Bath Ankylosing Spondylitis Radiology Index, CRP C-reactive protein, ESR erythrocyte sedimentation rate, NS not significant
  2. a For qualitative variables as percentage (%) and for quantitative variables as mean ± standard deviation (SD)