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Table 2 Genotype and allele analyses of BDNF in patients with fibromyalgia and healthy controlsa

From: Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study

Marker

Genotype/allele

Contol, n (%)

Fibromyalgia, n (%)

Exact p valueb

OR (95% CI), p valuec

OR (95% CI), p value, adjusted by age, sex‡

rs2883187

C/C

115 (27.5)

100 (24.4)

0.218

1

1

C/T

220 (52.6)

208 (50.9)

 

1.087 (0.783–1.510), p = 0.617

1.044 (0.747–1.458), p = 0.802

T/T

83 (19.9)

101 (24.7)

 

1.399 (0.943–2.078), p = 0.096

1.340 (0.897–2.002), p = 0.152

C

450 (53.8)

408 (49.9)

0.119

1

 

T

386 (46.2)

410 (50.1)

 

1.172 (0.966–1.421), p = 0.108

1.147 (0.943–1.395), p = 0.171

rs7103873

G/G

113 (27.8)

98 (24.0)

0.245

1

1

C/G

210 (51.6)

208 (51.0)

 

1.142 (0.820–1.591), p = 0.432

1.110 (0.791–1.556), p = 0.546

C/C

84 (20.6)

102 (25.0)

 

1.400 (0.943–2.080), p = 0.095

1.345 (0.899–2.010), p = 0.149

G

436 (53.6)

404 (49.5)

0.112

1

 

C

378 (46.4)

412 (50.5)

 

1.176 (0.968–1.429), p = 0.102

1.153 (0.946–1.405), p = 0.158

rs7103411

C/C

120 (28.5)

128 (31.3)

0.638

1

1

C/T

208 (49.4)

198 (48.4)

 

0.892 (0.651–1.224), p = 0.48

0.884 (0.641–1.220), p = 0.454

T/T

93 (22.1)

83 (20.3)

 

0.837 (0.568–1.232), p = 0.366

0.865 (0.584–1.280), p = 0.468

C

448 (53.2)

454 (55.5)

0.374

1

 

T

394 (46.8)

364 (44.5)

 

0.912 (0.751–1.106), p = 0.348

0.925 (0.76–1.125), p = 0.435

rs10835210

C/C

204 (49.4)

196 (48.0)

0.725

1

1

A/C

175 (42.4)

172 (42.2)

 

1.023 (0.767–1.364), p = 0.877

0.991 (0.740–1.326), p = 0.949

A/A

34 (8.2)

40 (9.8)

 

1.224 (0.745–2.014), p = 0.425

1.183 (0.714–1.957), p = 0.514

C

583 (70.6)

564 (69.1)

0.554

1

 

A

243 (29.4)

252 (30.9)

 

1.072 (0.868–1.324), p = 0.518

1.048 (0.846–1.297), p = 0.671

rs11030104

A/A

101 (24.0)

126 (31.0)

0.031

1

1

A/G

205 (48.8)

196 (48.2)

 

0.766 (0.553–1.063), p = 0.111

0.758 (0.544–1.057), p = 0.102

G/G

114 (27.1)

85 (20.9)

 

0.598 (0.407–0.877), p = 0.009

0.619 (0.419–0.913), p = 0.016

A

407 (48.5)

448 (55.0)

0.009

1

 

G

433 (51.5)

366 (45.0)

 

0.768 (0.633–0.932), p = 0.007

0.781 (0.641–0.95), p = 0.013

rs12273539

C/C

283 (67.1)

268 (65.4)

0.101

1

1

C/T

132 (31.3)

125 (30.5)

 

1 (0.744–1.345), p = 1

1.009 (0.747–1.362), p = 0.955

T/T

7 (1.7)

17 (4.1)

 

2.564 (1.047–6.282), p = 0.039

2.586 (1.052–6.36), p = 0.038

C

698 (82.7)

661 (80.6)

0.299

1

 

T

146 (17.3)

159 (19.4)

 

1.150 (0.897–1.475), p = 0.27

1.161 (0.902–1.493), p = 0.246

rs11030102

C/C

419 (99.3)

402 (98.5)

0.334

1

1

C/G

3 (0.7)

6 (1.5)

 

2.085 (0.518–8.392), p = 0.301

2.129 (0.524–8.649), p = 0.291

C

841 (99.6)

810 (99.3)

0.335

1

 

G

3 (0.4)

6 (0.7)

 

2.077 (0.518–8.326), p = 0.302

2.12 (0.524–8.58), p = 0.292

rs11030101

A/A

208 (49.5)

197 (48.3)

0.752

1

1

A/T

178 (42.4)

172 (42.2)

 

1.020 (0.766–1.358), p = 0.891

0.985 (0.737–1.317), p = 0.92

T/T

34 (8.1)

39 (9.6)

 

1.211 (0.735–1.996), p = 0.452

1.152 (0.694–1.912), p = 0.583

A

594 (70.7)

566 (69.4)

0.585

1

 

T

246 (29.3)

250 (30.6)

 

1.067 (0.864–1.316), p = 0.548

1.036 (0.837–1.283), p = 0.743

rs6265

G/G

96 (22.9)

87 (21.3)

0.770

1

1

A/G

204 (48.7)

197 (48.3)

 

1.066 (0.751–1.512), p = 0.722

1.017 (0.712–1.451), p = 0.928

A/A

119 (28.4)

124 (30.4)

 

1.150 (0.783–1.688), p = 0.476

1.110 (0.752–1.638), p = 0.599

G

396 (47.3)

371 (45.5)

0.496

1

 

A

442 (52.7)

445 (54.5)

 

1.075 (0.886–1.304), p = 0.466

1.058 (0.869–1.287), p = 0.575

rs7124442

C/C

2 (0.5)

0 (0)

0.574

1

1

C/T

51 (12.1)

47 (11.5)

 

718,117.521 (0-Inf), p = 0.972

683,123.831 (0-Inf), p = 0.972

T/T

368 (87.4)

360 (88.5)

 

762,294.038 (0-Inf), p = 0.971

682,163.974 (0-Inf), p = 0.972

C

55 (6.5)

47 (5.8)

0.590

1

 

T

787 (93.5)

767 (94.2)

 

1.140 (0.763–1.705), p = 0.521

1.078 (0.716–1.623), p = 0.72

  1. BDNF brain-derived neurotrophic factor
  2. aMissing data were excluded from the analyses: BDNF rs2883187 (5 controls), BDNF rs7103873 (1 patient and 16 controls), BDNF rs7103411 (2 controls), BDNF rs10835210 (1 patient and 10 controls), BDNF rs11030104 (2 patients and 3 controls), BDNF rs12273539 (1 control), BDNF rs11030102 (1 patient and 1 control), BDNF rs11030101 (1 patient and 3 controls), BDNF rs6265 (4 controls and 1 patient), and BDNF rs7124442 (2 patients and 2 controls)
  3. bValue was determined by Fisher’s exact test or χ2 test
  4. cLogistic regression analyses were used to calculate the OR (95% CI; confidence interval)
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Arthritis Research & Therapy

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