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Table 2 Genotype and allele analyses of BDNF in patients with fibromyalgia and healthy controlsa

From: Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study

Marker Genotype/allele Contol, n (%) Fibromyalgia, n (%) Exact p valueb OR (95% CI), p valuec OR (95% CI), p value, adjusted by age, sex‡
rs2883187 C/C 115 (27.5) 100 (24.4) 0.218 1 1
C/T 220 (52.6) 208 (50.9)   1.087 (0.783–1.510), p = 0.617 1.044 (0.747–1.458), p = 0.802
T/T 83 (19.9) 101 (24.7)   1.399 (0.943–2.078), p = 0.096 1.340 (0.897–2.002), p = 0.152
C 450 (53.8) 408 (49.9) 0.119 1  
T 386 (46.2) 410 (50.1)   1.172 (0.966–1.421), p = 0.108 1.147 (0.943–1.395), p = 0.171
rs7103873 G/G 113 (27.8) 98 (24.0) 0.245 1 1
C/G 210 (51.6) 208 (51.0)   1.142 (0.820–1.591), p = 0.432 1.110 (0.791–1.556), p = 0.546
C/C 84 (20.6) 102 (25.0)   1.400 (0.943–2.080), p = 0.095 1.345 (0.899–2.010), p = 0.149
G 436 (53.6) 404 (49.5) 0.112 1  
C 378 (46.4) 412 (50.5)   1.176 (0.968–1.429), p = 0.102 1.153 (0.946–1.405), p = 0.158
rs7103411 C/C 120 (28.5) 128 (31.3) 0.638 1 1
C/T 208 (49.4) 198 (48.4)   0.892 (0.651–1.224), p = 0.48 0.884 (0.641–1.220), p = 0.454
T/T 93 (22.1) 83 (20.3)   0.837 (0.568–1.232), p = 0.366 0.865 (0.584–1.280), p = 0.468
C 448 (53.2) 454 (55.5) 0.374 1  
T 394 (46.8) 364 (44.5)   0.912 (0.751–1.106), p = 0.348 0.925 (0.76–1.125), p = 0.435
rs10835210 C/C 204 (49.4) 196 (48.0) 0.725 1 1
A/C 175 (42.4) 172 (42.2)   1.023 (0.767–1.364), p = 0.877 0.991 (0.740–1.326), p = 0.949
A/A 34 (8.2) 40 (9.8)   1.224 (0.745–2.014), p = 0.425 1.183 (0.714–1.957), p = 0.514
C 583 (70.6) 564 (69.1) 0.554 1  
A 243 (29.4) 252 (30.9)   1.072 (0.868–1.324), p = 0.518 1.048 (0.846–1.297), p = 0.671
rs11030104 A/A 101 (24.0) 126 (31.0) 0.031 1 1
A/G 205 (48.8) 196 (48.2)   0.766 (0.553–1.063), p = 0.111 0.758 (0.544–1.057), p = 0.102
G/G 114 (27.1) 85 (20.9)   0.598 (0.407–0.877), p = 0.009 0.619 (0.419–0.913), p = 0.016
A 407 (48.5) 448 (55.0) 0.009 1  
G 433 (51.5) 366 (45.0)   0.768 (0.633–0.932), p = 0.007 0.781 (0.641–0.95), p = 0.013
rs12273539 C/C 283 (67.1) 268 (65.4) 0.101 1 1
C/T 132 (31.3) 125 (30.5)   1 (0.744–1.345), p = 1 1.009 (0.747–1.362), p = 0.955
T/T 7 (1.7) 17 (4.1)   2.564 (1.047–6.282), p = 0.039 2.586 (1.052–6.36), p = 0.038
C 698 (82.7) 661 (80.6) 0.299 1  
T 146 (17.3) 159 (19.4)   1.150 (0.897–1.475), p = 0.27 1.161 (0.902–1.493), p = 0.246
rs11030102 C/C 419 (99.3) 402 (98.5) 0.334 1 1
C/G 3 (0.7) 6 (1.5)   2.085 (0.518–8.392), p = 0.301 2.129 (0.524–8.649), p = 0.291
C 841 (99.6) 810 (99.3) 0.335 1  
G 3 (0.4) 6 (0.7)   2.077 (0.518–8.326), p = 0.302 2.12 (0.524–8.58), p = 0.292
rs11030101 A/A 208 (49.5) 197 (48.3) 0.752 1 1
A/T 178 (42.4) 172 (42.2)   1.020 (0.766–1.358), p = 0.891 0.985 (0.737–1.317), p = 0.92
T/T 34 (8.1) 39 (9.6)   1.211 (0.735–1.996), p = 0.452 1.152 (0.694–1.912), p = 0.583
A 594 (70.7) 566 (69.4) 0.585 1  
T 246 (29.3) 250 (30.6)   1.067 (0.864–1.316), p = 0.548 1.036 (0.837–1.283), p = 0.743
rs6265 G/G 96 (22.9) 87 (21.3) 0.770 1 1
A/G 204 (48.7) 197 (48.3)   1.066 (0.751–1.512), p = 0.722 1.017 (0.712–1.451), p = 0.928
A/A 119 (28.4) 124 (30.4)   1.150 (0.783–1.688), p = 0.476 1.110 (0.752–1.638), p = 0.599
G 396 (47.3) 371 (45.5) 0.496 1  
A 442 (52.7) 445 (54.5)   1.075 (0.886–1.304), p = 0.466 1.058 (0.869–1.287), p = 0.575
rs7124442 C/C 2 (0.5) 0 (0) 0.574 1 1
C/T 51 (12.1) 47 (11.5)   718,117.521 (0-Inf), p = 0.972 683,123.831 (0-Inf), p = 0.972
T/T 368 (87.4) 360 (88.5)   762,294.038 (0-Inf), p = 0.971 682,163.974 (0-Inf), p = 0.972
C 55 (6.5) 47 (5.8) 0.590 1  
T 787 (93.5) 767 (94.2)   1.140 (0.763–1.705), p = 0.521 1.078 (0.716–1.623), p = 0.72
  1. BDNF brain-derived neurotrophic factor
  2. aMissing data were excluded from the analyses: BDNF rs2883187 (5 controls), BDNF rs7103873 (1 patient and 16 controls), BDNF rs7103411 (2 controls), BDNF rs10835210 (1 patient and 10 controls), BDNF rs11030104 (2 patients and 3 controls), BDNF rs12273539 (1 control), BDNF rs11030102 (1 patient and 1 control), BDNF rs11030101 (1 patient and 3 controls), BDNF rs6265 (4 controls and 1 patient), and BDNF rs7124442 (2 patients and 2 controls)
  3. bValue was determined by Fisher’s exact test or χ2 test
  4. cLogistic regression analyses were used to calculate the OR (95% CI; confidence interval)
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Arthritis Research & Therapy

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