Fig. 6

Anti-inflammatory effect of monoclonal antibodies (mAbs) KH4–8 and KH7–33 on the expression of serum pro-inflammatory cytokines of the collagen-induced arthritis mouse model. The serum levels of adiponectin, interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and receptor activator of nuclear factor-kappa Β ligand (RANKL) were analyzed by using the Luminex system. Values are expressed as mean ± standard error of the mean. The expression levels of the factors were compared between groups (n = 8) by using the Mann–Whitney test. **P <0.01, *P <0.05 versus normal (NOR) group, and ^##P <0.01, ^##P <0.05 versus the control (CON) group. Abbreviations: ns not significant, pre prednisolone