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Table 2 Correlations and associations between the MBDA score and disease activity measures

From: The multi-biomarker disease activity score tracks response to rituximab treatment in rheumatoid arthritis patients: a post hoc analysis of three cohort studies

Measure Time point or period for comparison with MBDA score Number of available samples r p value β (95% CI)1 p value
DAS28-ESR BL 46 0.52 < 0.01 0.05 (0.02–0.07) < 0.01
6 M 42 0.49 < 0.01 0.06 (0.02–0.09) 0.01
38 0.60 < 0.01 0.05 (0.01–0.08) 0.02
ESR BL 44 0.75 < 0.01 1.20 (0.71–1.70) < 0.01
6 M 42 0.66 < 0.01 0.81 (0.36–1.26) < 0.01
37 0.48 < 0.01 0.57 (−0.03–1.17) 0.06
DAS28-hsCRP2 BL 25 0.51 < 0.01 0.06 (0.02–0.10) 0.01
6 M 24 0.45 0.03 0.06 (0.02–0.10) < 0.01
23 0.48 0.02 0.05 (0.00–0.09) < 0.05
hsCRP2 BL 25 0.80 < 0.01 1.24 (0.72–1.76) < 0.01
6 M 24 0.80 < 0.01 0.75 (0.41–1.10) < 0.01
23 0.71 < 0.01 0.90 (0.60–1.21) < 0.01
CRP BL 46 0.75 < 0.01 1.07 (0.62–1.52) < 0.01
6 M 40 0.76 < 0.01 0.82 (0.58–1.06) < 0.01
37 0.59 < 0.01 0.68 (0.18–1.19) < 0.01
SJC28 BL 48 0.15 0.32 0.10 (−0.06–0.26) 0.22
6 M 42 0.26 0.10 0.14 (−0.01–0.28) 0.06
40 0.42 < 0.01 0.12 (−0.04–0.29) 0.14
TJC28 BL 48 0.23 0.12 0.17 (0.02–0.32) 0.03
6 M 42 0.25 0.11 0.17 (−0.01–0.34) 0.06
40 0.28 0.08 0.04 (−0.15–0.23) 0.67
VAS-GH BL 48 0.20 0.18 0.34 (−0.12–0.79) 0.14
6 M 42 0.27 0.09 0.46 (−0.08–0.99) 0.09
40 0.36 0.02 0.74 (0.08–1.40) 0.03
HAQ BL 39 0.02 0.91 0.06 (−0.06–0.02) 0.30
6 M 41 −0.03 0.85 −0.01 (− 0.01–0.01) 0.84
34 0.19 0.28 0.00 (−0.01–0.01) 0.77
  1. DAS28 disease activity score using 28 joints, ESR erythrocyte sedimentation rate, hsCRP high-sensitivity C-reactive protein, SJC28 swollen joint count assessing 28 joints, TJC28 tender joint count assessing 28 joints, VAS-GH patient visual analogue scale for general health, HAQ health assessment questionnaire, MBDA multi-biomarker disease activity, BL MBDA score and measure both at baseline, 6 M MBDA score and measure both at month 6, ∆ change in MBDA score and measure, both from baseline to month 6, r Spearman’s rank correlation, CI confidence interval
  2. 1β: regression coefficient from multivariable linear regression analysis, after adjustment by age, gender, smoking status, RF status, ACPA status, and cohort
  3. 2HORUS cohort only