Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis

Table 2 Simple and multiple linear regression analyses for assessing the correlations among different clinical parameters and expression levels of IL-23-regulated miRNAs in T cells of patients with ankylosing spondylitis

	miR-7114-5p	miR-1914-3p	miR-211-3p	miR-4449	miR-29b-1-5p
Sex (M/F)	−0.112 (0.784)	0.317 (0.564)	0.473 (0.366)	0.294 (0.520)	−0.207 (0.731)
Age (per 10 years)	−0.085 (0.505)	0.021 (0.919)	0.030 (0.875)	−0.159 (0.337)	−0.031 (0.889)
CRP (per 1 mg/dl)	−0.005 (0.920)	0.008 (0.915)	0.073 (0.299)	0.054 (0.380)	0.020 (0.804)
Anti-TNF therapy (yes/no)	0.490 (0.099^a)	0.351 (0.466)	0.330 (0.474)	0.286 (0.475)	0.029 (0.965)
ASDAS-CRP	−0.194 (0.250)	−0.941 (0.727)	−0.121 (0.639)	0.230 (0.304)	0.278 (0.358)

Abbreviations: ASDAS Ankylosing Spondylitis Disease Activity Score, CRP C-reactive protein, TNF Tumor necrosis factor
Values are correlation coefficients and (P values) from simple linear regression analyses
^aAfter adjusting for age and sex in the multiple linear regression analysis, patients with AS using anti-TNF therapy had a significant 1.56-fold increase (P = 0.048; 95% CI, 1.00–2.43) in miR-7114-5p expression compared with those who did not receive anti-TNF therapy

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