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Table 2 Simple and multiple linear regression analyses for assessing the correlations among different clinical parameters and expression levels of IL-23-regulated miRNAs in T cells of patients with ankylosing spondylitis

From: Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis

  miR-7114-5p miR-1914-3p miR-211-3p miR-4449 miR-29b-1-5p
Sex (M/F) −0.112 (0.784) 0.317 (0.564) 0.473 (0.366) 0.294 (0.520) −0.207 (0.731)
Age (per 10 years) −0.085 (0.505) 0.021 (0.919) 0.030 (0.875) −0.159 (0.337) −0.031 (0.889)
CRP (per 1 mg/dl) −0.005 (0.920) 0.008 (0.915) 0.073 (0.299) 0.054 (0.380) 0.020 (0.804)
Anti-TNF therapy (yes/no) 0.490 (0.099a) 0.351 (0.466) 0.330 (0.474) 0.286 (0.475) 0.029 (0.965)
ASDAS-CRP −0.194 (0.250) −0.941 (0.727) −0.121 (0.639) 0.230 (0.304) 0.278 (0.358)
  1. Abbreviations: ASDAS Ankylosing Spondylitis Disease Activity Score, CRP C-reactive protein, TNF Tumor necrosis factor
  2. Values are correlation coefficients and (P values) from simple linear regression analyses
  3. aAfter adjusting for age and sex in the multiple linear regression analysis, patients with AS using anti-TNF therapy had a significant 1.56-fold increase (P = 0.048; 95% CI, 1.00–2.43) in miR-7114-5p expression compared with those who did not receive anti-TNF therapy